The average life expectancy of a male born on the Pine Ridge reservation in South Dakota today is 40 years old-the lowest life expectancy of all peoples not only in the U.S. but also in the entire Western Hemisphere. Written by and for nurses, this is the first text to focus exclusively on American Indian health and nursing. It addresses the profound disparities in policy, health care law, and health outcomes that affect American Indians, and describes how these disparities, bound into the cultural, environmental, historical, and geopolitical fabric of American Indian society, are responsible for the marked lack of wellbeing of American Indians. American Indian nurse authors, natives of nine unique American Indian cultures, address the four domains of health-physical, mental, spiritual, and emotional--within each region to underscore the many stunning disparities of opportunity for health and wellbeing within the American Indian culture as opposed to those of ""Anglo"" culture. In an era of cultural competency, these expert nurse authors bring awareness about what is perhaps the least understood minority population in the U.S. The text covers the history of American Indians with a focus on the drastic changes that occurred following European contact. Included are relevant journal articles, historical reports, interviews with tribal health officials, and case studies. The book addresses issues surrounding American Indian nursing and nursing education, and health care within nine unique American Indian cultural populations. Also discussed are the health care needs of American Indians living in urban areas. Additionally, the book examines the future of American Indian Nursing in regard to the Affordable Care Act. Key Features: Focuses exclusively on American Indian health and nursing-the first book to do so Written by predominately American Indian nurses Covers four domains of health: physical, mental, spiritual and emotional Highlights nine specific cultural areas of Indian country, each with its own unique history and context Includes chapter objectives, end-of-chapter review questions, and case studies

This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.

Increased longevity and better health are changing the nature of family life. In the context of changes in the world of work, increased divorce and a declining welfare state, multi-generation or 'beanpole families' are a potential resource for family support. Focusing on four-generation families and the two central careers of the life course - employment and care - Working and Caring Over the Twentieth Century explores this question. Based upon new research that employed biographical methods, it maps in detail from 1910 to the late 1990s the lives of men and women as great-grandparents, grandparents and parents. The book provides unique insights into processes of change and continuity in family lives and the ways in which different generations of men and women make sense of their lives.

A vast array of natural organic compounds, the products of primary and secondary metabolism, occur in plants. The purpose of this dictionary is to provide basic information, including structural formulae, on plant constituents, with emphasis on those that are biologically active. This text profiles over 3000 substances from phenolics and alkaloids through carbohydrates and plant glycosides to oils and triterpenoids. For each substance, the author presents the trivial name, synonyms, structural type, chemical structure showing stereochemistry, molecular weight and formula, natural occurrence, biological activity and commercial or other use. Key references are provided for each class and subclass. It also reviews antifungal agents, with CAS numbers wherever possible, for all compounds to provide ready access to the original literature.

Handbook of Excipients The Handbook of Pharmaceutical Excipients is internationally recognised as the world's most authoritative source of information on pharmaceutical excipients. It is the definitive comprehensive guide to uses, properties and safety of excipients providing scientists and researchers with a one stop resource when researching an excipient. All of the 400+ monographs are also thoroughly cross-referenced and indexed to allow their identification by chemical, non-proprietary or trade names. Extensive content updates in the new edition include: - Over 420 fully referenced excipient monographs, many including IR, Raman, and NIR spectra - 13 new monographs including several amino acids and hydrated silicon dioxide - 250 existing monographs reviewed - New chapters providing support to the formulator, such as excipient selection for orally inhaled and also injectable formulations. Unique Benefits - The world's authoritative source of information on pharmaceutical excipients - International Scope: Recognized globally as the authority on the uses, properties and safety of excipients. - Written by over 170 expert pharmaceutical scientists - One stop resource when researching an excipient Contents - Biological Effects of Pharmaceutical Excipients - The Selection of Excipients for Injectable Formulations - The Selection of Excipients for Orally Inhaled Dosage Forms - The History of Excipients - The Use of Counterions and Coformers in the Creation of Salt and Co-Crystal forms of Active Pharmaceutical Ingredients (APIs) - Over 420 Monographs benefiting from a standardized, easy-to-use template including: - Pharmacopoeial information from the UK, Europe, Japan and the United States where relevant - non-proprietary names and synonyms - chemical name and structure, CAS Registry number, empirical formula, molecular weight - functional category, applications and incompatibilities - material description and typical excipient properties - safety, stability, storage and handling information - method of drug manufacture - related substances - primary references - editorial comments - author details and revision date

"It is a very thorough and up-to-date clinical handbook and reference for the primary care Doc or nurse. . . . if you have a favorite Family Doc or Internist or Nurse Practitioner--or administrator--and you want them to have a nice gift, buy them this book. But read it before you give it away."
--JOURNAL OF NEUROTHERAPY

The Handbook of Mind-Body Medicine for Primary Care introduces an evidence-based mind-body approach to the medical and behavioral problems of primary care patients. Evidence-based mind-body practice draws on the best available scientific research and advocates the integration of well-documented mind-body therapies into primary health care. The handbook summarizes current mind-body practice and provides an overview of the basic techniques, including biofeedback, neurofeedback, relaxation therapies, hypnotherapy, cognitive-behavioral therapies, acupuncture, and spiritual therapies. The editors also thoroughly demonstrate the application of these techniques to common disorders such as headache, chronic pain, and essential hypertension, as well as anxiety, depression, chronic fatigue syndrome, fibromyalgia, and sleep disorders.

The Handbook includes educational models with guidelines for physicians, nurses, physicians? assistants, and behavioral health practitioners. The book closes with a look at the existential and spiritual side of the human encounter with sickness and disease. This handbook will benefit a wide variety of health providers in primary care.

The Handbook is divided into four parts:

• Part I introduces the conceptual models from the psychophysiological perspective for understanding functional medical problems.
• Part II describes specific clinical tools and interventions.
• Part III overviews the best documented cognitive-behavioral approaches and alternative therapies to common disorders.
• Part IV provides educational models for practitioners in each of the mind-body disciplines.

Donald Moss, Ph.D., is Director of Chronic Pain Services at West Michigan Behavioral Health Services.

Angele V. McGrady, Ph.D., is a Professor of Psychiatry and Adjunct Professor of Physiology and Molecular Medicine at Medical College of Ohio.

Terence C. Davies, MD, is Chairman of Family and Community Medicine at Eastern Virginia Medical School.

Ian Wickramasekera, Ph.D., is a Professor of psychology at Saybrook Graduate School, Clinical Professor of Psychiatry at Stanford Medical School, and Professor of Family Medicine at Eastern Virginia Medical School.

Authored by highly respected nurse educators, leaders, and scholars, this text focuses on the power of nursing to make substantive contributions to improving the health of all populations. It delivers an in-depth examination and analysis of current issues and determinants of health as outlined by Healthy People 2020 and addresses AACN's Essentials of Doctoral Education for Advanced Nursing Practice.Along with principles, pathways, and imperatives pertinent to achieving health equity, the text discusses the evolution of thinking from eliminating health disparities to achieving health equity, and examines population-based and population-specific inequities in health status and outcomes. Highlighting the importance of interprofessional collaboration, it surveys timely initiatives, programs, and professionals-within and outside of the health sciences-who are important partners in efforts toward achieving health equity. Chapters are highly templated to include objectives, key concepts, critical-thinking questions, discussion questions, and resources. Key Features: Focuses on the power of nursing to make substantive contributions to improving the health of all populations Examines principles, pathways, and imperatives pertinent to achieving health equity Discusses economic, environmental, personal, social, and structural factors that impact health status and outcomes Highlights the importance of interprofessional collaboration in achieving health equity Addresses AACN's Essentials of Doctoral Education for Advanced Nursing Practice Demonstrates key concepts and stimulates reflection through critical-thinking and discussion questions Purchase includes access to the eBook for use on most mobile devices or computers

This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.

Increased longevity and better health are changing the nature of family life. In the context of changes in the world of work, increased divorce and a declining welfare state, multi-generation or 'beanpole families' are a potential resource for family support. Focusing on four-generation families and the two central careers of the life course - employment and care - Working and Caring Over the Twentieth Century explores this question. Based upon new research that employed biographical methods, it maps in detail from 1910 to the late 1990s the lives of men and women as great-grandparents, grandparents and parents. The book provides unique insights into processes of change and continuity in family lives and the ways in which different generations of men and women make sense of their lives.