|
Showing 1 - 3 of
3 matches in All Departments
|
Recombinant Protein Production with Prokaryotic and Eukaryotic Cells. A Comparative View on Host Physiology - Selected articles from the Meeting of the EFB Section on Microbial Physiology, Semmering, Austria, 5th-8th October 2000 (Paperback, Softcover reprint of hardcover 1st ed. 2001)
Otto-Wilhelm Merten, D. Mattanovich, C. Lang, G. Larsson, P. Neubauer, …
|
R5,771
Discovery Miles 57 710
|
Ships in 10 - 15 working days
|
More then 20 years have passed now since the first recombinant
protein producing microorganisms have been developed. In the
meanwhile, numerous proteins have been produced in bacteria, yeasts
and filamentous fungi, as weIl as higher eukaryotic cells, and even
entire plants and animals. Many recombinant proteins are on the
market today, and some of them reached substantial market volumes.
On the first sight one would expect the technology - including the
physiology of the host strains - to be optimised in detail after a
20 year's period of development. However, several constraints have
limited the incentive for optimisation, especially in the
pharmaceutical industry like the urge to proceed quickly or the
requirement to define the production parameters for registration
early in the development phase. The additional expenses for
registration of a new production strain often prohibits a change to
an optimised strain. A continuous optimisation of the entire
production process is not feasible for the same reasons.
|
Recombinant Protein Production with Prokaryotic and Eukaryotic Cells. A Comparative View on Host Physiology - Selected articles from the Meeting of the EFB Section on Microbial Physiology, Semmering, Austria, 5th-8th October 2000 (Hardcover, 2001 ed.)
Otto-Wilhelm Merten, D. Mattanovich, C. Lang, G. Larsson, P. Neubauer, …
|
R6,016
Discovery Miles 60 160
|
Ships in 10 - 15 working days
|
The general field of fundamental and applied biotechnology becomes
increasingly important for the production of biologicals for human
and veterinary use, by using prokaryotic and eukaryotic
microorganisms. The papers in the present book are refereed
articles compiled from oral and poster presentations from the EFB
Meeting on Recombinant Protein Production with Prokaryotic and
Eukaryotic Cells. A Comparative View on Host Physiology, which was
organized in Semmering/A from 5th to 8th October 2000. A special
feature of this meeting was the comparison of different classes of
host cells, mainly bacteria, yeasts, filamentous fungi, and animal
cells, which made obvious that many physiological features of
recombinant protein formation, like cell nutrition, stress
responses, protein folding and secretion, or genetic stability,
follow similar patterns in different expression systems. This
comparative aspect is by far the point of most interest because
such comparisons are rarely done, and if they are done, their
results are most often kept secret by the companies who generated
them. Audience: Presently, a comparable book does not exist because
the compiling of manuscripts from all fields of biotechnology
(prokaryotic as well as eukaryotic, up to animal cell
biotechnology) is not done in general. This particularity makes
this book very interesting for postgraduate students and
professionals in the large field of biotechnology who want to get a
more global view on the current state of the expression of
recombinant biologicals in different host cell systems, the
physiological problems associated with the use of different
expression systems, potential approaches to solve such difficulties
bymetabolic engineering or the use of other host cells, and the
cooperation between process development and strain improvement,
which is crucial for the optimisation of both the production strain
and the process. This book should be in every library of an
institution/organization involved in biotechnology.
|
You may like...
Loot
Nadine Gordimer
Paperback
(2)
R398
R330
Discovery Miles 3 300
|