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Ulcerative colitis and Crohn's disease remain a great therapeutic
challenge to the medical community. In recent years knowledge about
the pathogenesis of these diseases has progressed rapidly but the
cause of the diseases remains completely unknown. It has become
clear that dysregulation of the mucosal immune system is the basis
for the chronic evolution of the diseases in a genetically
susceptible population. Exciting new therapeutic approaches have
been attempted in the last couple of years and cytokine and
anti-cytokine treatments in particular seem very promising,
especially in intractable disease. The format of the Falk Symposium
106 on Advances in Inflammatory Bowel Diseases', held in Brussels,
Belgium, June 18-20, 1998, was somewhat innovative as each session
attempted to link the new insights into pathogenetic mechanisms
with new therapeutic approaches, resulting in optimal information
transfer. The classic therapeutic schemes were updated with a
special focus on step-wise build-up of therapy.
Although the first description of patients with what we now call
Crohn's disease or ulcerative colitis was published well before
1900, both disorders seem to be diseases of the twentieth century.
At the very start of the twenty-first century, it therefore seems
appropriate to look back and at the same time look forward and to
assess what knowledge has been gained during the last 100 years and
in what direction research and thereby clinical practice will go in
the future. This book, the proceedings of Falk Symposium No. 111
held in Freiburg, Germany, on June 19-20 1999, contains
contributions from experienced senior scientists on the state of
the art in pathophysiology, diagnosis and treatment, together with
unpublished and new findings from young researchers. Basic
scientists and clinicians are thereby involved in an exchange of
information which will lead to new directions for future research
and clinical management of inflammatory bowel diseases.
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