At present, we do not fully understand at what stage of the evolution of living matter the first traces of defense reactions occurred. We even do not fully understand how and why immune systems reached their contem porary state in advanced vertebrates and man. It may be expected that in the near future these questions will be answered by comparative and develop mental biology. Together with an extraordinary explosion of our knowledge about immunity of mammals including man, an increase in the interests concerning origin and development of immune mechanisms at lower stages of the phylogeny can be observed. The search for simple types of immune mechanisms in less complex but still evolutionary successful animals is promising and may contribute to better understanding of highly complex immune adaptive responses in mammals. It is important to note that comparative and evolutionary immunology differs greatly from other branches of biomedical science. Apart from immunology and molecular biology, a specialist in this discipline has to be familiar with every detail of taxonomy, comparative anatomy, physiology, embryology, and even with the phyletic relationships of animals. Probably no monography could deal with the entire animal kingdom, because, in many cases, the insights into questions about immune mecha nisms of many animal groupings or phyla, and their possible evolutionary implications, are unknown or just now beginning to take shape. For the moment, our knowledge on such matters relies upon reconstructions of ideas that we have deduced from studies on members of relative taxa."

This book represents an evolutionary approach to defense mechanisms of all living organisms. The results achieved in developmental and comparative immunology are among the most interesting data in immunology. These results have great impact on our understanding fundamental problems of the pathology of the human immune system. At the same time, the field of evolutionary immunology provides not only inspiration for further investigation in biomedicine, but also a number of results applicable in clinical and commercial practice.

This book evaluates the advantages and limitations of studying the development of defense reactions. In addition to reviewing the major and crucial achievements of the past, the book offers a comprehensive state-of-the-art treatise focused primarily on the latest experiments described in the last few years.