Gene probes, whether RNA or DNA, have played a central role in the rapid development of molecular biology. The wide variety of applications is matched by a considerable diversity in the methods used for generating probes, a complete account of which would be very difficult to make. Instead, this second volume in the series combines a selection of newer gene probe procedures with a review of the most important established methods, together with some examples of the ways in which gene probes can be applied. In doing so, the book aims to act not only as an introductory manual for newcomers to the field, but also as a means of broadening the horizons of existing researchers.