Microinjection (G. Sczakiel et al.). How to Make Glass Microtools for the Injection of Isolated Plant Sperm Cells into Embryo Sac Cells Using a Microforge (C.J. Keijzer). Application of Confocal Microscopy for the Study of Neuronal Organization in Human Cortical Areas after Microinjection of Lucifer Yellow (P.V. Belichenko et al.). Flourescent Probes (R.W. Horobin, F. RashidDoubell). Flourescent Phospholipids in Membrane and Lipoprotein Research (A. Hermetter et al.). Selection of Flourescent Golgi Complex Probes Using StructureActivity Relationship Models (F. RashidDoubell, R.W. Horobin). WholeCell PatchClamping (B. Van Duijn et al.). Flourescent Analysis of Replication and Intermediates of Chromatin Folding in Nuclei of Mammalian Cells (G. Banfalvi). Autoflourescence in Potato Tuber Phellem (T. Hendriks et al.). Quantitative Localization of HIV Proteins in Mammalian Cells (L.E.A. Amet et al.). Concepts of the Cytometric Approach (S.C. Brown). 14 additional articles. Index.

Toxicological and pharmacological effects arise when chemicals interact with biophysical functions in discrete cell types. Researchers have a continuing need to screen novel compounds for their potential therapeutic needs and, once these have been discovered, to understand their molecular actions. Histochemistry can be used to facilitate the development of the knowledge on the distribution of a compound, the receptors to which it binds and the modulation of the physiological functions that are being investigated.