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Oncology has developed as a subspecialty of medicine with unique
and often complex clinical problems. This handbook ofhematologic
and oncologic emer gencies provides a compact, concise, yet
comprehensive guide to the manage ment of a variety of difficult
clinical situations. The authors of the various chapters are all
clinicians with experience in the management of these difficult
patients. Their efforts provide insight and a ready source of
practical infor mation which lends itself to use in the clinic and
in the inpatient ward. The authors sincerely hope that this
handbook will be of service to house officers and fellows alike, as
they develop skills in the management of the emergent problems of
patients with hematologic and other neoplasms. Janice P. Dutcher
Peter H. Wiernik Bronx, New York;; Contents 1. Syndrome of
Inappropriate Antidiuretic Hormone Secretion and Hyponatremia . . .
. . . . . . . . . . . . . . . . . . . . . 000 . . . . . . . . . . .
Stuart L. Marcus, M.D., Ph.D., and Joachim Z. Fuks, M.D. 1.
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . 1 2. Mechanisms . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . 3 3. Etiology . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . 3 4. Diagnosis
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . 5 5. Treatment . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. 6 References . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . 8 2. Acute Tumor Lysis
Syndrome: Prevention and Management . . 9 Stuart L. Marcus, M.D.,
Ph.D., and Avi I. Einz;ig, M.D. 1. Introduction . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. 9 2. Risk Factors for the Development of Azotemia in Acute Tumor
Lysis Syndrome........................................... 10 3.
Metabolic Abnormalities That Occur during Acute Tumor Lysis
Syndrome . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . 11 . . . . . . . . . . . . . . 4. Prevention of Acute
Tumor Lysis Syndrome: Management prior to Beginning Chemotherapy .
. . . . . . . . . . . . . . . . . . . . . . . . 13 . . . . . . . .
. . 5. Posttreatment Management: Indications for Dialysis . . . . .
. . . . . 14 . . References . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . 15 . . . . . . . . . . . . . ."
The European School of Oncology came into existence to respond to a
need for informa tion, education and training in the field of the
diagnosis and treatment of cancer. There are two main reasons why
such an initiative was considered necessary. Firstly, the teaching
of oncology requires a rigorously multidisciplinary approach which
is difficult for the Universi ties to put into practice since their
system is mainly disciplinary orientated. Secondly, the rate of
technological development that impinges on the diagnosis and
treatment of cancer has been so rapid that it is not an easy task
for medical faculties to adapt their curricula flexibly. With its
residential courses for organ pathologies and the seminars on new
techniques (laser, monoclonal antibodies, imaging techniques etc.)
or on the principal therapeutic controversies (conservative or
mutilating surgery, primary or adjuvant chemotherapy, radiotherapy
alone or integrated), it is the ambition of the European School of
Oncology to fill a cultural and scientific gap and, thereby, create
a bridge between the University and Industry and between these two
and daily medical practice.
Oncology has developed as a subspecialty of medicine with unique
and often complex clinical problems. This handbook ofhematologic
and oncologic emer gencies provides a compact, concise, yet
comprehensive guide to the manage ment of a variety of difficult
clinical situations. The authors of the various chapters are all
clinicians with experience in the management of these difficult
patients. Their efforts provide insight and a ready source of
practical infor mation which lends itself to use in the clinic and
in the inpatient ward. The authors sincerely hope that this
handbook will be of service to house officers and fellows alike, as
they develop skills in the management of the emergent problems of
patients with hematologic and other neoplasms. Janice P. Dutcher
Peter H. Wiernik Bronx, New York;; Contents 1. Syndrome of
Inappropriate Antidiuretic Hormone Secretion and Hyponatremia . . .
. . . . . . . . . . . . . . . . . . . . . 000 . . . . . . . . . . .
Stuart L. Marcus, M.D., Ph.D., and Joachim Z. Fuks, M.D. 1.
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . 1 2. Mechanisms . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . 3 3. Etiology . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . 3 4. Diagnosis
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . 5 5. Treatment . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. 6 References . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . 8 2. Acute Tumor Lysis
Syndrome: Prevention and Management . . 9 Stuart L. Marcus, M.D.,
Ph.D., and Avi I. Einz;ig, M.D. 1. Introduction . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. 9 2. Risk Factors for the Development of Azotemia in Acute Tumor
Lysis Syndrome........................................... 10 3.
Metabolic Abnormalities That Occur during Acute Tumor Lysis
Syndrome . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . 11 . . . . . . . . . . . . . . 4. Prevention of Acute
Tumor Lysis Syndrome: Management prior to Beginning Chemotherapy .
. . . . . . . . . . . . . . . . . . . . . . . . 13 . . . . . . . .
. . 5. Posttreatment Management: Indications for Dialysis . . . . .
. . . . . 14 . . References . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . 15 . . . . . . . . . . . . . ."
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