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The synthetic chemistry of carbohydrates has advanced at a scarcely
equalled rate in the last 25 years, due to the great interest of
biologically active natural products coritaining sugar moieties. It
suffices to note that in the review by J. D. Dutcher appearing in
"Advances in Carbohydrate Chemistry" vol. 18, 1963, only the
structures of less than ten aminodeoxy sugars were reported. This
book deals exclusively with a single class of carbohydrates, namely
the aminodeoxy sugars of antibiotics, the most popular of which is
probably daunosamine, a compound for which more than 20 different
synthetic approaches have been reported in the literature since the
publication of its structure in 1964. No compound in the
3-amino-2-deoxY-L-hexose series had been prepared by chemical
synthesis when we started our synthetic work in this field in 1972
on the wave of the successful therapeutic applications of
adriamycin. The compounds with xylo stereochemistry were unknown
even in the more easily accessible D-series. The size of this book
documents the rapid development of the field. I wish to add that
the improvements of chemical methodology reported in. the volume
outspan the specific field and are of importance in the design of
synthetic approaches to other carbohydrate structures. These also
include compounds involved in chemical interactions of great
biological interest, but hitherto un explained at the molecular
level, such as those related with cell recognition, adhesiveness
and differentiation."
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