This book constitutes the refereed post-conference proceedings of the Interdisciplinary Workshop on Trust, Identity, Privacy, and Security in the Digital Economy, DETIPS 2020; the First International Workshop on Dependability and Safety of Emerging Cloud and Fog Systems, DeSECSys 2020; Third International Workshop on Multimedia Privacy and Security, MPS 2020; and the Second Workshop on Security, Privacy, Organizations, and Systems Engineering, SPOSE 2020; held in Guildford, UK, in September 2020, in conjunction with the 25th European Symposium on Research in Computer Security, ESORICS 2020. A total of 42 papers was submitted. For the DETIPS Workshop 8 regular papers were selected for presentation. Topics of interest address various aspect of the core areas in relation to digital economy. For the DeSECSys Workshop 4 regular papers are included. The workshop had the objective of fostering collaboration and discussion among cyber-security researchers and practitioners to discuss the various facets and trade-o s of cyber security. In particular, applications, opportunities and possible shortcomings of novel security technologies and their integration in emerging application domains. For the MPS Workshop 4 regular papers are presented which cover topics related to the security and privacy of multimedia systems of Internet-based video conferencing systems (e.g., Zoom, Microsoft Teams, Google Meet), online chatrooms (e.g., Slack), as well as other services to support telework capabilities. For the SPOSE Workshop 3 full papers were accepted for publication. They reflect the discussion, exchange, and development of ideas and questions regarding the design and engineering of technical security and privacy mechanisms with particular reference to organizational contexts.