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Phospholipases generate lipid signaling molecules through their
hydrolytic action on phospholipids and are known to regulate
function of a variety of cells under normal and diseased
conditions. While several physiological, biochemical and molecular
techniques have identified key players involved in different
disease processes, phospholipases have also emerged as critical
players in the pathogenesis of a number of different diseases
including cancer and heart disease. In addition, phospholipases are
also implicated in such conditions as brain disorder/injury, kidney
and immune cell dysfunction. Phospholipases in Health and Disease
is a compilation of review articles dedicated to the study of the
field with respect to biochemical and molecular mechanisms of
normal and abnormal cell function. The wide range of area covered
here is of interest to basic research scientists, clinicians and
graduate students, who are engaged in studying pathophysiological
basis of a variety of diseases. Furthermore, this book highlights
the potential of the different phospholipases as therapeutic
targets as well as part of prevention strategies. Twenty three
articles in this book are organized in four sections that are
designed to emphasize the most characterized forms of the
phospholipases in mammalian cells. The first section discusses
general aspect of phospholipases. Section two covers the role and
function of phospholipase A in different pathophysiological
conditions. The third section is focussed on phospholipase C which
is believed to play a central role in transmembrane signaling. The
final section covers phospholipase D which is present in a variety
of different cells. The book illustrates that the activation of
phospholipases is of fundamental importance in signal transduction
affecting cell function. Overall, this book discusses the diverse
mechanisms of phospholipase mediated signal transduction in
different pathophysiological conditions and raises the possibility
of specific forms of phospholipases serving as novel targets for
drug development.
Global health has been challenged with the dawning of the era of
the obesity epidemic, and thus as a consequence, strategies to
reduce obesity have become public health priorities. According to
the United Nations, obesity has been identified as a concern for
achieving Sustainable Development Goals. Obesity is a serious
health problem with an increased risk of several common diseases
including diabetes, cardiovascular disease, and cancer. Although
the fundamental cause of obesity and overweight is an imbalance
between calorie intake and calorie expenditure, the underlying
biochemical and metabolic processes that cause obesity are not
fully understood. Two earlier volumes dedicated to the subject of
obesity, published in the series "Advances in Biochemistry in
Health and Disease" focused on the pathophysiology of
obesity-induced health complications and the biochemistry of
cardiovascular dysfunction in obesity. This book brings together
contributions from international experts in the field to describe
advancements on the mechanisms leading to development of obesity
and related complications. There are 21 chapters in two different
parts in this book, comprising of Part I: Pathophysiologic
Mechanisms of Obesity (11 chapters) and Part II: Therapeutic
Mechanisms of Obesity (10 chapters). This book will serve as a
resource and be of interest to health professionals, medical
students, fellows, residents and graduate students. It will also
evoke innovative research and effective approaches for the
prevention of obesity. This volume will accentuate that obesity is
a major health hazard in its own right and that appropriate public
health measures should be implemented to prevent or reduce or even
reverse the impact of this global chronic disease.
Obesity is an independent risk factor for cardiovascular disease
(CVD) in adults as well as in obese children. This book will
provide a description of the impact of obesity on the
cardiovascular system and increased predisposition to CVD. It will
identify the major biochemical mechanisms that lead to the
occurrence of myocardial abnormalities and vascular alterations in
obesity. We will also have some discussion on the biochemistry of
the so-called obesity paradox in relation to CVD. The contributors
to this book are international experts on obesity and associated
cardiovascular complications. This book is also uniquely positioned
as it focuses on the biochemistry of obesity-induced cardiovascular
dysfunction. There are 20 chapters in 2 different parts in this
book, comprising of Part A: Pathophysiology of Cardiovascular
Complications in Obesity (11 chapters) and Part B: Modification of
Cardiovascular Dysfunction in obesity (9 chapters). The intent of
this volume is to provide current and basic understanding of the
biochemical mechanisms of obesity induced cardiovascular
dysfunction that will be of value not only to cardiologists and
other allied health professionals, but will also stimulate and
motivate biomedical researchers and scientists to find the way to
prevent the epidemic of obesity associated cardiovascular
abnormalities. Furthermore, this book will serve as a highly useful
resource for medical students, fellows, residents and graduate
students with an interest in the cardiovascular system. In summary,
this book covers a broad range of biochemical mechanisms of
obesity-induced cardiovascular complications. We hope that the
reader will understand that obesity is linked to an increase in the
risk and occurrence of fatal CVD. Furthermore, the underlying
message presented in the book is that the cause of obesity related
disorders is complex and that understanding the biochemistry of
cardiovascular dysfunction may contribute to the development of
novel interventions for the prevention and treatment of obesity
associated comorbidities.
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