Hot Melt Extrusion can be simply defined as the process of forming a new material by forcing it through an orifice or die under controlled conditions, such as temperature, mixing, feed-rate and pressure. Hot Melt Extrusion is the process of embedding drug in a polymeric carrier. Hot Melt Extrusion is the process of converting a raw material into a product of uniform shape and density by forcing it through a die under controlled conditions. In recent years, interest in hot melt extrusion techniques for pharmaceutical applications has grown significantly. Hot melt extrusion (HME) is an established manufacturing process that has been used in the plastics and food industry since the 1930s. It was first developed in the early 20th century by the plastics industry as a means of producing different shapes for a variety of industrial and domestic applications.

Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene flanked by two hydrophilic chains of polyoxyethylene. Now a day, Poloxamer are widely used in different drug delivery systems due to its biodegradability, high solubility and low toxicity. Poloxamers contain both hydrophilic and hydrophobic part, so they are used widely as surfactant and emulsifier in the formulation. Poloxamer are used in solid dispersion as solubility enhancer. Pluronic grade has thermo reversible gelation property, liquid at room temperature and convert gel at body temperature, so it is used in the control release formulation. Poloxamer are used for improve the stability of Nanoparticle and liposome. Poloxamers are used in solid suppositories for improve the dissolution of poorly soluble drugs and decrease the rectal irritation compare to conventional polymer like polyethylene glycol. Poloxamer are also used in the biological preparation as stabilizer.

After oral administration, the majority of drug molecules are absorbed across the small intestine and enter the systemic circulation via the portal vein and the liver. For some highly lipophilic drugs (typically log PN5, lipid solubility 50 mg/g), however, association with lymph lipoproteins in the enterocyte leads to transport to the systemic circulation via the intestinal lymph. The attendant delivery benefits associated with lymphatic drug transport include a reduction in first pass metabolism and lymphatic exposure to drug concentrations orders of magnitude higher than that attained in systemic blood. In the current review we briefly describe the mechanisms by which drug molecules access the lymph and the formulation strategies that may be utilised to enhance lymphatic drug transport. Specific focus is directed toward recent advances in understanding regarding the impact of lipid source (both endogenous and exogenous) and intracellular lipid trafficking pathways on lymphatic drug transport and enterocyte based first pass metabolism.

An herbal alternative to asthma is better way for treatment of asthma. Various herbal medicines recognize that immune system functioning can play a vital role in helping to control the symptoms of asthma and strengthen the body's defenses against environmental allergens. Herbal medicines like ephedra, ginger, chamomile, elderberry, licorice, mullein, stinging nettle etc are very beneficial in asthma. Scientists have found evidence to support herbal's wide range of medicinal actions. These actions include the lowering of cholesterol levels, relief for allergies and asthma etc. Herbs have been used by people for longer than we have been keeping written record. Originally they were found in the wild, by the gatherers and used for lots of different things. I light here, the use of herbals in asthma. It aims to tap into the body's own healing mechanism by transforming the "triggers" of such attacks as part of the remedy. Opinions of different authors are say that herbal medication is better way for asthma treatment.

The importance of coatings has increased hugely during the modern era of technology. Coating is defined as a material (usually a liquid) which is applied onto a surface and appears as either a continuous or discontinuous film after drying. Coatings are mainly applied on surfaces for decorative, protective or functional purposes but in most cases it is a combination of these. The properties of coating films are determined by the types of binders, pigments and miscellaneous additives used in the formulation. The terms "coating" will be used synonymously in this book. In general, collectively or individually, paints, varnishes and lacquers are termed as coating.