This book constitutes the refereed proceedings of the 15th International Conference on Reachability Problems, RP 2021, held in Liverpool, UK in October 2021. The 6 full papers presented were carefully reviewed and selected from 27 submissions. In addition, 4 invited papers were included in this volume. The RP proceedings cover topics such as reachability for infinite state systems; rewriting systems; reachability analysis in counter/timed/cellular/communicating automata; Petri nets; computational aspects of semigroups, groups, and rings; reachability in dynamical and hybrid systems; frontiers between decidable and undecidable reachability problems; complexity and decidability aspects; predictability in iterative maps; and new computational paradigms. Chapter 'Recent Advances on Reachability Problems for Valence Systems' is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.