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Systemic Lupus Erythematosus: Methods and Protocols describe a
number of genetic, biochemical and immunological techniques. These
techniques provide an advancing understanding of the pathology,
breakdown of the immune system and therapeutic challenges of SLE in
both humans and animal models. Written in the highly successful
Methods in Molecular Biology series format, chapters include
introductions to their respective topics, lists of the necessary
materials and reagents, step-by-step, readily reproducible
laboratory protocols and key tips on troubleshooting and avoiding
known pitfalls. Authoritative and practical, Systemic Lupus
Erythematosus: Methods and Protocols appeal to biomedical and
clinical scientists in a number of pathology disciplines at the
doctoral and post-doctoral level.
Systemic Lupus Erythematosus: Methods and Protocols describe a
number of genetic, biochemical and immunological techniques. These
techniques provide an advancing understanding of the pathology,
breakdown of the immune system and therapeutic challenges of SLE in
both humans and animal models. Written in the highly successful
Methods in Molecular Biology series format, chapters include
introductions to their respective topics, lists of the necessary
materials and reagents, step-by-step, readily reproducible
laboratory protocols and key tips on troubleshooting and avoiding
known pitfalls. Authoritative and practical, Systemic Lupus
Erythematosus: Methods and Protocols appeal to biomedical and
clinical scientists in a number of pathology disciplines at the
doctoral and post-doctoral level.
The book focuses on the latest discoveries on calreticulin,
calnexin and other endoplasmic reticulum proteins. Calreticulin has
been implicated to affect diverse cellular function and play a role
in many pathologies including protein folding disorders, cardiac
pathologies, cancer and autoimmunity. This book contains
contributions from the world leaders in the area of endoplasmic
reticulum function, protein folding, Calcium homeostasis and
autoimmunity. It raises many intriguing questions about
calreticulin, calnexin and the endoplasmic reticulum and gives a
unique opportunity to realize the significance of these
calcium-binding chaperones. The book is unique in every respect and
we are not aware of any other publication focusing on these aspects
of endoplasmic reticulum biology. Because of a central role of
endoplasmic reticulum, calreticulin and calnexin in virtually all
cellular functions, the book should be of interest to everyone in
the biological sciences.
The book focuses on the latest discoveries on calreticulin,
calnexin and other endoplasmic reticulum proteins. Calreticulin has
been implicated to affect diverse cellular function and play a role
in many pathologies including protein folding disorders, cardiac
pathologies, cancer and autoimmunity. This book contains
contributions from the world leaders in the area of endoplasmic
reticulum function, protein folding, Calcium homeostasis and
autoimmunity. It raises many intriguing questions about
calreticulin, calnexin and the endoplasmic reticulum and gives a
unique opportunity to realize the significance of these
calcium-binding chaperones. The book is unique in every respect and
we are not aware of any other publication focusing on these aspects
of endoplasmic reticulum biology. Because of a central role of
endoplasmic reticulum, calreticulin and calnexin in virtually all
cellular functions, the book should be of interest to everyone in
the biological sciences.
The relationship between systematics and ecology has recently been
invigorated, and developed a long way from the "old" field of
comparative biology. This change has been two-fold. Advances in
phylogenetic research have allowed explicit phylogenetic hypotheses
to be constructed for a range of different groups of organisms, and
ecologists are now more aware that organism traits are influenced
by the interaction of past and present. This volume discusses the
impact of these modern phylogenetic methods on ecology, especially
those using comparative methods.
Although unification of these areas has proved difficult, a number
of conclusions can be drawn from the text. These include the need
for a "working" bridge between evolutionary biologists using
logic-based cladistic methods and those using probability-based
statistical methods, for care in the selection of tree types for
comparative studies and for systematists to attempt to analyse
ecologically important groups.
Comparative ecologists and systematists need to come together to
develop these ideas further, but this volume presents a very useful
starting point for all those interested in systematics and ecology.
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