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Up to 40 volumes are planned for this concise monograph series,
which focuses on the implementation of various engineering
principles in the conception, design, development, analysis and
operation of biomedical, biotechnological and nanotechnology
systems and applications. In this monograph, the authors discuss
the current progress in the medical application of impedimetric
biosensors, along with the key challenges in the field. First, a
general overview of biosensor development, structure and function
is presented, followed by a detailed discussion of impedimetric
biosensors and the principles of electrochemical impedance
spectroscopy. Next, the current state-of-the art in terms of the
science and technology underpinning impedance-based biosensors is
reviewed in detail. The layer-by-layer construction of impedimetric
sensors is described, including the design of electrodes, their
nano-modification, transducer surface functionalisation and the
attachment of different bioreceptors. The current challenges of
translating lab-based biosensor platforms into
commercially-available devices that function with real patient
samples at the POC are presented; this includes a consideration of
systems integration, microfluidics and biosensor regeneration. The
final section of this monograph describes case studies of
successful impedance-based biosensors for the detection of a range
of analytes from small molecules up to whole microorganisms.
Finally, the authors put forward future perspectives for the
clinical applications of impedimetric biosensors.
The use of biosensors is accelerating at an enormous rate.
Increasingly robust and rapid sensors are being developed for the
detection of a wide range of biological molecules and chemicals
within the environment. "Biosensors: Methods Express" is a
practical guide to all the major classes of electrical and
mechanical biosensors in current use. Every chapter discusses the
merits and limitations of potential approaches and then provides
selected tried-and-tested protocols, with full guidance to ensure
success. This book is one which will benefit all researchers who
use, or seek to use, biosensors in their research.
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