Major advances have been made in recent years in clarifying the molecular properties of the cytochrome P-450 system. These advances stem, in practical terms, from the generally recognized importance of cytochrome P-450 in the metabolism of drugs and in the bioactivation of xenobiotics to toxic products. The fascinating multiplicity and differential regulation of cytochrome P-450 isozymes, and their ability to catalyze extraordinarily difficult chemical transformations, have independently drawn many chemists and biochemists into the P-450 circle. Progress in the field, from a technical point of view, has been propelled by the de velopment of reliable procedures for the purification of membrane-bound enzymes, by the growing repertoire of molecular biological techniques, and by the development of chemical models that mimic the catalytic action of P-450. As a result, our understanding of the P-450 system is moving from the descriptive, pharmacological level into the tangible realm of atomic detail. The rapid progress and multidisciplinary character of the cytochrome P-450 field, which cuts across the lines that traditionally divide disciplines as diverse as inorganic chemistry and genetics, have created a need for an up-to-date evaluation of the advances that have been made. It is hoped that this book, with its molecular focus on the cytochrome P-450 system, will alleviate this need. The authors of the individual chapters have strived to emphasize recent results without sacrificing the background required to make their chapters comprehensible to informed nonspecialists.

Major advances have been made in recent years in clarifying the molecular properties of the cytochrome P-450 system. These advances stem, in practical terms, from the generally recognized importance of cytochrome P-450 in the metabolism of drugs and in the bioactivation of xenobiotics to toxic products. The fascinating multiplicity and differential regulation of cytochrome P-450 isozymes, and their ability to catalyze extraordinarily difficult chemical transformations, have independently drawn many chemists and biochemists into the P-450 circle. Progress in the field, from a technical point of view, has been propelled by the de velopment of reliable procedures for the purification of membrane-bound enzymes, by the growing repertoire of molecular biological techniques, and by the development of chemical models that mimic the catalytic action of P-450. As a result, our understanding of the P-450 system is moving from the descriptive, pharmacological level into the tangible realm of atomic detail. The rapid progress and multidisciplinary character of the cytochrome P-450 field, which cuts across the lines that traditionally divide disciplines as diverse as inorganic chemistry and genetics, have created a need for an up-to-date evaluation of the advances that have been made. It is hoped that this book, with its molecular focus on the cytochrome P-450 system, will alleviate this need. The authors of the individual chapters have strived to emphasize recent results without sacrificing the background required to make their chapters comprehensible to informed nonspecialists.

Featuring contributions from leading scholar-activists, People Power demonstrates how the lessons of history can inform the building of new social justice movements today. This volume is inspired by the pathbreaking life and work of writer, activist, and historian Lawrence "Larry" Goodwyn. As a radical Texas journalist and a political organizer, Goodwyn participated in historic changes ushered in by grassroots activism in the 1950s and '60s. Professor and cofounder of the Oral History Program at Duke University, Goodwyn wrote about movements built by Latino farm workers, Polish trade unionists, civil rights activists, and others who challenged the status quo. The essays in this volume examine Goodwyn's influence in political and social movements, his approaches to teaching and writing, and his insights into the long history behind contemporary activism. People Power will generate deep discussions about the potential of democracy amid the multiple crises of our time. What motivates ordinary people to move from kitchen table conversations to civic engagement? What do the chronicles of past social movements tell us about how to confront the real blocks of racism and the idea that Americans are somehow "exceptional"? Contributors provide key experiential knowledge that will help today's scholars and community organizers address these pressing questions. Contributors: Donnel Baird | Charles C. Bolton | William Chafe | Ernesto Cortes Jr. | Marsha J. Tyson Daring | Benj DeMott | Scott Ellsworth |Faulkner Fox | Elise Goldwasser | Wade Goodwyn | William Greider | Jim Hightower | Wesley C. Hogan | Wendy Jacobs | Thelma Kithcart | Max Krochmal | Connie L. Lester | Adam Lioz | Andrew Neather | Paul Ortiz | Gunther Peck | Timothy B. Tyson | G. C. Waldrep | Lane Windham | Peter H. Wood

In this penetrating examination of African American politics and culture, Paul Ortiz throws a powerful light on the struggle of black Floridians to create the first statewide civil rights movement against Jim Crow. Concentrating on the period between the end of slavery and the election of 1920, Emancipation Betrayed vividly demonstrates that the decades leading up to the historic voter registration drive of 1919-20 were marked by intense battles during which African Americans struck for higher wages, took up arms to prevent lynching, forged independent political alliances, boycotted segregated streetcars, and created a democratic historical memory of the Civil War and Reconstruction. Contrary to previous claims that African Americans made few strides toward building an effective civil rights movement during this period, Ortiz documents how black Floridians formed mutual aid organizations--secret societies, women's clubs, labor unions, and churches--to bolster dignity and survival in the harsh climate of Florida, which had the highest lynching rate of any state in the union. African Americans called on these institutions to build a statewide movement to regain the right to vote after World War I. African American women played a decisive role in the campaign as they mobilized in the months leading up to the passage of the Nineteenth Amendment. The 1920 contest culminated in the bloodiest Election Day in modern American history, when white supremacists and the Ku Klux Klan violently, and with state sanction, prevented African Americans from voting. Ortiz's eloquent interpretation of the many ways that black Floridians fought to expand the meaning of freedom beyond formal equality and his broader consideration of how people resist oppression and create new social movements illuminate a strategic era of United States history and reveal how the legacy of legal segregation continues to play itself out to this day.