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Major advances have been made in recent years in clarifying the
molecular properties of the cytochrome P-450 system. These advances
stem, in practical terms, from the generally recognized importance
of cytochrome P-450 in the metabolism of drugs and in the
bioactivation of xenobiotics to toxic products. The fascinating
multiplicity and differential regulation of cytochrome P-450
isozymes, and their ability to catalyze extraordinarily difficult
chemical transformations, have independently drawn many chemists
and biochemists into the P-450 circle. Progress in the field, from
a technical point of view, has been propelled by the de velopment
of reliable procedures for the purification of membrane-bound
enzymes, by the growing repertoire of molecular biological
techniques, and by the development of chemical models that mimic
the catalytic action of P-450. As a result, our understanding of
the P-450 system is moving from the descriptive, pharmacological
level into the tangible realm of atomic detail. The rapid progress
and multidisciplinary character of the cytochrome P-450 field,
which cuts across the lines that traditionally divide disciplines
as diverse as inorganic chemistry and genetics, have created a need
for an up-to-date evaluation of the advances that have been made.
It is hoped that this book, with its molecular focus on the
cytochrome P-450 system, will alleviate this need. The authors of
the individual chapters have strived to emphasize recent results
without sacrificing the background required to make their chapters
comprehensible to informed nonspecialists.
Major advances have been made in recent years in clarifying the
molecular properties of the cytochrome P-450 system. These advances
stem, in practical terms, from the generally recognized importance
of cytochrome P-450 in the metabolism of drugs and in the
bioactivation of xenobiotics to toxic products. The fascinating
multiplicity and differential regulation of cytochrome P-450
isozymes, and their ability to catalyze extraordinarily difficult
chemical transformations, have independently drawn many chemists
and biochemists into the P-450 circle. Progress in the field, from
a technical point of view, has been propelled by the de velopment
of reliable procedures for the purification of membrane-bound
enzymes, by the growing repertoire of molecular biological
techniques, and by the development of chemical models that mimic
the catalytic action of P-450. As a result, our understanding of
the P-450 system is moving from the descriptive, pharmacological
level into the tangible realm of atomic detail. The rapid progress
and multidisciplinary character of the cytochrome P-450 field,
which cuts across the lines that traditionally divide disciplines
as diverse as inorganic chemistry and genetics, have created a need
for an up-to-date evaluation of the advances that have been made.
It is hoped that this book, with its molecular focus on the
cytochrome P-450 system, will alleviate this need. The authors of
the individual chapters have strived to emphasize recent results
without sacrificing the background required to make their chapters
comprehensible to informed nonspecialists.
Featuring contributions from leading scholar-activists, People
Power demonstrates how the lessons of history can inform the
building of new social justice movements today. This volume is
inspired by the pathbreaking life and work of writer, activist, and
historian Lawrence "Larry" Goodwyn. As a radical Texas journalist
and a political organizer, Goodwyn participated in historic changes
ushered in by grassroots activism in the 1950s and '60s. Professor
and cofounder of the Oral History Program at Duke University,
Goodwyn wrote about movements built by Latino farm workers, Polish
trade unionists, civil rights activists, and others who challenged
the status quo. The essays in this volume examine Goodwyn's
influence in political and social movements, his approaches to
teaching and writing, and his insights into the long history behind
contemporary activism. People Power will generate deep discussions
about the potential of democracy amid the multiple crises of our
time. What motivates ordinary people to move from kitchen table
conversations to civic engagement? What do the chronicles of past
social movements tell us about how to confront the real blocks of
racism and the idea that Americans are somehow "exceptional"?
Contributors provide key experiential knowledge that will help
today's scholars and community organizers address these pressing
questions. Contributors: Donnel Baird | Charles C. Bolton | William
Chafe | Ernesto Cortes Jr. | Marsha J. Tyson Daring | Benj DeMott |
Scott Ellsworth |Faulkner Fox | Elise Goldwasser | Wade Goodwyn |
William Greider | Jim Hightower | Wesley C. Hogan | Wendy Jacobs |
Thelma Kithcart | Max Krochmal | Connie L. Lester | Adam Lioz |
Andrew Neather | Paul Ortiz | Gunther Peck | Timothy B. Tyson | G.
C. Waldrep | Lane Windham | Peter H. Wood
In this penetrating examination of African American politics and
culture, Paul Ortiz throws a powerful light on the struggle of
black Floridians to create the first statewide civil rights
movement against Jim Crow. Concentrating on the period between the
end of slavery and the election of 1920, Emancipation Betrayed
vividly demonstrates that the decades leading up to the historic
voter registration drive of 1919-20 were marked by intense battles
during which African Americans struck for higher wages, took up
arms to prevent lynching, forged independent political alliances,
boycotted segregated streetcars, and created a democratic
historical memory of the Civil War and Reconstruction. Contrary to
previous claims that African Americans made few strides toward
building an effective civil rights movement during this period,
Ortiz documents how black Floridians formed mutual aid
organizations--secret societies, women's clubs, labor unions, and
churches--to bolster dignity and survival in the harsh climate of
Florida, which had the highest lynching rate of any state in the
union. African Americans called on these institutions to build a
statewide movement to regain the right to vote after World War I.
African American women played a decisive role in the campaign as
they mobilized in the months leading up to the passage of the
Nineteenth Amendment. The 1920 contest culminated in the bloodiest
Election Day in modern American history, when white supremacists
and the Ku Klux Klan violently, and with state sanction, prevented
African Americans from voting. Ortiz's eloquent interpretation of
the many ways that black Floridians fought to expand the meaning of
freedom beyond formal equality and his broader consideration of how
people resist oppression and create new social movements illuminate
a strategic era of United States history and reveal how the legacy
of legal segregation continues to play itself out to this day.
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