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Synthetic Biology - A Primer gives a broad overview of the emerging
field of synthetic biology and the foundational concepts on which
it is built. It will be of interest to final year undergraduates,
postgraduates and established researchers who are interested in
learning about this exciting new field. The book introduces readers
to fundamental concepts in molecular biology and engineering and
then explores the two major themes for synthetic biology, namely
'bottom-up' and 'top-down' engineering approaches. 'Top-down'
engineering utilises a conceptual framework of engineering and
systematic design to build new biological systems by integrating
robustly characterised biological parts into an existing system
through the use of extensive mathematical modelling. The
'bottom-up' approach involves the design and building of synthetic
protocells using basic chemical and biochemical building blocks
from scratch. Exemplars of cutting-edge applications designed using
synthetic biology principles are presented, including the
production of novel biofuels from renewable feedstocks, microbial
synthesis of pharmaceuticals and fine chemicals, and the design and
implementation of biosensors to detect infections and environmental
waste. The book also uses the Internationally Genetically
Engineered Machine (iGEM) competition to illustrate the power of
synthetic biology as an innovative research and training science.
Finally, the primer includes a chapter on the ethical, legal and
societal issues surrounding synthetic biology, illustrating the
integration of social sciences in synthetic biology research.
Synthetic Biology - A Primer (Revised Edition) presents an updated
overview of the field of synthetic biology and the foundational
concepts on which it is built. This revised edition includes new
literature references, working and updated URL links, plus some new
figures and text where progress in the field has been made.The book
introduces readers to fundamental concepts in molecular biology and
engineering and then explores the two major themes for synthetic
biology, namely 'bottom-up' and 'top-down' engineering approaches.
'Top-down' engineering uses a conceptual framework of systematic
design and engineering principles focused around the
Design-Build-Test cycle and mathematical modelling. The 'bottom-up'
approach involves the design and building of synthetic protocells
using basic chemical and biochemical building blocks from scratch
exploring the fundamental basis of living systems.Examples of
cutting-edge applications designed using synthetic biology
principles are presented, including: The book also describes the
Internationally Genetically Engineered Machine (iGEM) competition,
which brings together students and young researchers from around
the world to carry out summer projects in synthetic biology.
Finally, the primer includes a chapter on the ethical, legal and
societal issues surrounding synthetic biology, illustrating the
integration of social sciences into synthetic biology
research.Final year undergraduates, postgraduates and established
researchers interested in learning about the interdisciplinary
field of synthetic biology will benefit from this up-to-date primer
on synthetic biology.
Synthetic Biology - A Primer gives a broad overview of the emerging
field of synthetic biology and the foundational concepts on which
it is built. It will be of interest to final year undergraduates,
postgraduates and established researchers who are interested in
learning about this exciting new field. The book introduces readers
to fundamental concepts in molecular biology and engineering and
then explores the two major themes for synthetic biology, namely
'bottom-up' and 'top-down' engineering approaches. 'Top-down'
engineering utilises a conceptual framework of engineering and
systematic design to build new biological systems by integrating
robustly characterised biological parts into an existing system
through the use of extensive mathematical modelling. The
'bottom-up' approach involves the design and building of synthetic
protocells using basic chemical and biochemical building blocks
from scratch. Exemplars of cutting-edge applications designed using
synthetic biology principles are presented, including the
production of novel biofuels from renewable feedstocks, microbial
synthesis of pharmaceuticals and fine chemicals, and the design and
implementation of biosensors to detect infections and environmental
waste. The book also uses the Internationally Genetically
Engineered Machine (iGEM) competition to illustrate the power of
synthetic biology as an innovative research and training science.
Finally, the primer includes a chapter on the ethical, legal and
societal issues surrounding synthetic biology, illustrating the
integration of social sciences in synthetic biology research.
Synthetic Biology - A Primer (Revised Edition) presents an updated
overview of the field of synthetic biology and the foundational
concepts on which it is built. This revised edition includes new
literature references, working and updated URL links, plus some new
figures and text where progress in the field has been made.The book
introduces readers to fundamental concepts in molecular biology and
engineering and then explores the two major themes for synthetic
biology, namely 'bottom-up' and 'top-down' engineering approaches.
'Top-down' engineering uses a conceptual framework of systematic
design and engineering principles focused around the
Design-Build-Test cycle and mathematical modelling. The 'bottom-up'
approach involves the design and building of synthetic protocells
using basic chemical and biochemical building blocks from scratch
exploring the fundamental basis of living systems.Examples of
cutting-edge applications designed using synthetic biology
principles are presented, including: The book also describes the
Internationally Genetically Engineered Machine (iGEM) competition,
which brings together students and young researchers from around
the world to carry out summer projects in synthetic biology.
Finally, the primer includes a chapter on the ethical, legal and
societal issues surrounding synthetic biology, illustrating the
integration of social sciences into synthetic biology
research.Final year undergraduates, postgraduates and established
researchers interested in learning about the interdisciplinary
field of synthetic biology will benefit from this up-to-date primer
on synthetic biology.
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