|
Showing 1 - 2 of
2 matches in All Departments
Includes 500 complex illustrations in full color.
* Thorough cross referencing and Definition Entries (one paragraph
dictionary articles).
* Reference list contains not only traditional material, but also
FTP and HTTP sites and similar entries to electronic sources.
* Contributions from more than 300 leading computational
chemists.
* von Rague Schleyer is also the editor of Wiley's well-known
Journal of Computational Chemistry.
Polar organometallic compounds are indispensable for the synthetic
chemist. As this book shows, these almost ideal reagents are easy
to prepare with high specificity under mild conditions and yet
react quite readily with a great variety of substrates. Many
compounds can be metallated directly at positions which would
otherwise be difficult to substitute. Functional groups and
heteroatoms already present in a molecule direct metallation to
sites in their vicinity. The rules which govern polar
organometallic chemistry often are not dominated by the usual
n-delocalization and inductive effects; dipolar interactions,
chelation, polarization, etc. often can be much more important.
This affords novel synthetic opportunities. A good example is the
development of a basically new type of aromatic substitution
chemistry not based on positively charged intermediates. Seebach's
injunction, "Thinking of polar organometallic compounds as
carbanions is an impoverishment rather than a simplification"
(International Symposium, Chemistry of Carbanions, Durham 1984),
stresses the need to consider the metal not only as an integral,
but perhaps also as the key component of these reagents. Rather
than wandering off as solvated cations and acting as uninvolved
spectators, the metals, rather than the anion moieties, can
initiate and govern the subsequent reactions. To the founders of
this field, e. g. Grignard, Ziegler, Gilman, Wittig, and their
followers, the metal was critical. The title of Schlosser's book,
"Polare Organometalle," certainly was apt.
|
You may like...
Merry Christmas
Mariah Carey, Walter Afanasieff, …
CD
R122
R112
Discovery Miles 1 120
Tenet
John David Washington, Robert Pattinson
Blu-ray disc
(1)
R54
Discovery Miles 540
|
Email address subscribed successfully.
A activation email has been sent to you.
Please click the link in that email to activate your subscription.