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To meet the search for new therapeutic compounds this book
summarises the research on biologically active organic molecules
(chapters 1, 2 and 3), metal complexes with biological activity
(chapter 4), and shows the possibilities for co-ordination
chemistry in the planning of metal complexes with interesting
properties for application (chapters 5, 6, 7, 8, and 9). It should
be remembered that in the design of a new potentially active
metallodrug, beyond the nature of the metal, the choice of
appropriate ligands which affect the thermodynamic and kinetic
stability, as well as the solubility and lipophilicity of the
complexes is of paramount importance. The information contained in
the book concerns: 1) the interactions involving the members of the
Nuclear Receptor superfamily and their ligands; 2) the role of
chemokine ligands and their receptors in normal and disease
processes, and the emerging therapeutic approaches of using
chemokine antagonists for appropriately targeted therapy; 3) the
inhibition of alkaline phosphatases by calix[4]arenes
functionalysed at the macrocyclic upper rim by one or two
methylenebisphosphonic acid fragments; 4) the main biological
applications, enzyme modelling and antiproliferative and
antimicrobial activity of such scorpionate-type complexes, which
are classified by ligand and also by transition metal; 5) the
silver(I) discrete and polymeric coordination compounds bearing
1,3,5-triaza-7-phosphaadamantane or its derivatives towards
engineering functional silver-organic frameworks (MOFs); 6)
arylhydrazones of methylene active nitriles and their use as
starting materials for the generation of new organic and
coordination compounds; 7) amidophosphate ligands as promising
sensitisers of lanthanide ions emission; 8)
N-acetylsalicylhydrazidate as a versatile ligand for the synthesis
of higher nuclearity metal complexes, which are illustrated herein
along with their applications; 9) the chemistry and some
applications of formazans which can be used for the simultaneous
selective determination of several metal cations. All chapters were
compiled by renowned scientists, providing both beginners in the
field and advanced researchers with comprehensive information on
the subject.
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