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The Ultrastructure of Human Tumours: Applications in Diagnosis and
Research describes the core features as seen by transmission
electron microscopy, defining the different types of cellular
differentiation in tumours; this is relevant for tumour
nomenclature and diagnosis, which, in turn, are important for
tumour pathologists in their collaboration with oncologists for the
treatment of cancer patients. The book is divided into 8 chapters.
Following an introduction on technique and procedure, there are
chapters on epithelial tumours, melanocytic lesions, soft-tissue
and related tumours, lymphoma and leukaemia, CNS neoplasms and
neuroendocrine and neuronal tumours. Each chapter includes an
introductory text that puts the ultrastructural features in the
context of classical pathology. The book includes many new findings
and interpretations from well-known tumours, as well as
ultrastructural information on several newly described tumour
entities not dealt with in existing tumour ultrastructure
monographs. The book will especially be of value to tumour
pathologists who need to solve problem cases with the aid of
electron microscopy, but also to cancer research and tissue
engineering scientists working to develop anti-cancer and
stem-cell-based therapies. However, even those without access to
electron microscopy may also benefit from this book, since many of
the images provide an 'explanation' of the appearances of cells,
tissues and tumours familiar to pathologists and scientists from
light microscopy. In this respect, it is hoped that this book will
stimulate the wider use of electron microscopy in pathology. The
book is comprehensively referenced, 680 pages long and lavishly
illustrated with 757 figures. Dr. Brian Eyden is Consultant
Clinical Scientist and Dr. S. Sankar Banerjee Consultant
Histopathologist in the Department of Histopathology, Christie NHS
Foundation Trust, Manchester, UK; Dr. Yongxin Ru is Director of the
Department of Electron Microscopy, Institute of Hematology and
Blood Diseases Hospital, Tianjin, China; Pawel Liberski is
Professor in the Department of Molecular Pathology and
Neuropathology, Medical University Lodz, Poland.
This volume provides comprehensive information and detailed
laboratory protocols used in the study of prion diseases. The
chapters in this book cover topics such as: electron microscopy,
neuropathology, immunohistochemistry, and immune-gold electron
microscopy of prion diseases. Chapters also provide readers with
detailed information about kuru, the clinical description of prion
diseases, and the detection of prion protein and biomarkers. In
Neuromethods series style, chapters include the kind of detail and
key advice from the specialists needed to get successful results in
your laboratory. Cutting-edge and authoritative, Prion Diseases is
a valuable resource for researchers and scientists in the exciting
and rapidly growing field of prion disease research.
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