Pedro Martin has grown up hearing stories about his abuelito—his legendary crime-fighting, grandfather who was once a part of the Mexican Revolution! But that doesn’t mean Pedro is excited at the news that Abuelito is coming to live with their family. After all, Pedro has 8 brothers and sisters and the house is crowded enough! Still, Pedro piles into the Winnebago with his family for a road trip to Mexico to bring Abuelito home, and what follows is the trip of a lifetime, one filled with laughs and heartache. Along the way, Pedro finally connects with his abuelito and learns what it means to grow up and find his grito.

Nanotechnology for Oral Drug Delivery: From Concept to Applications discusses the current challenges of oral drug delivery, broadly revising the different physicochemical barriers faced by nanotechnolgy-based oral drug delivery systems, and highlighting the challenges of improving intestinal permeability and drug absorption. Oral delivery is the most widely used form of drug administration due to ease of ingestion, cost effectiveness, and versatility, by allowing for the accommodation of different types of drugs, having the highest patient compliance. In this book, a comprehensive overview of the most promising and up-to-date engineered and surface functionalized drug carrier systems, as well as opportunities for the development of novel and robust delivery platforms for oral drug administration are discussed. The relevance of controlling the physicochemical properties of the developed particle formulations, from size and shape to drug release profile are broadly reviewed. Advances in both in vitro and in vivo scenarios are discussed, focusing on the possibilities to study the biological-material interface. The industrial perspective on the production of nanotechnology-based oral drug delivery systems is also covered. Nanotechnology for Oral Drug Delivery: From Concept to Applications is essential reading for researchers, professors, advanced students and industry professionals working in the development, manufacturing and/or commercialization of nanotechnology-based systems for oral drug delivery, targeted drug delivery, controlled drug release, materials science and biomaterials, in vitro and in vivo testing of potential oral drug delivery technologies.

This astute volume brings together the latest expert research on adamantinomatous craniopharyngiomas (ACPs). ACPs are histologically benign but clinically aggressive tumors exhibiting a high propensity for local invasion into the hypothalamus, optic and vascular structures. These tumors, as well as the current treatments, may result in pan-hypopituitarism, diabetes insipidus, morbid obesity followed by type II diabetes mellitus, blindness, as well as serious behavioral and psychosocial impairments. Exploring in detail advances in both the understanding of tumor biology as well as clinical advances in patient management are explored in detail, this book will also look towards potential new treatment approaches. Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underlie the etiology of the majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke's pouch precursors. In addition, a role for tissue-specific adult pituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have been shown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy.

This volume collects contributions written by different experts in honor of Prof. Jaime Munoz Masque. It covers a wide variety of research topics, from differential geometry to algebra, but particularly focuses on the geometric formulation of variational calculus; geometric mechanics and field theories; symmetries and conservation laws of differential equations, and pseudo-Riemannian geometry of homogeneous spaces. It also discusses algebraic applications to cryptography and number theory. It offers state-of-the-art contributions in the context of current research trends. The final result is a challenging panoramic view of connecting problems that initially appear distant.

I'd like to know who in the world hasn't made more than one mistake a day. The answer is obvious, but that's not really the problem. It's that we don't know what we should do with the negative energy-by the way very toxic-that inevitably stays inside us when we don't properly handle our emotions and decisions about our mistakes. This powerful manual doesn't assume that we're saints, or much less, that we're perfect. What it seeks to show us is how we can free ourselves from the damage and distress associated with the errors that we commit, always with the aim of being able to feel better, grow, gain new skills, develop ourselves more fully, and stay in a process of continual improvement with no need to live as victims of these errors. As you read this manual, you will discover, among many other things, the damage done to human beings by the formidable React Without Thinking (RWT) virus and you'll also find out what to do to control it. Likewise, you will understand what guilt really is and how to transform the negative energy that inevitably accompanies it into positive energy. Errors are, perhaps, our best allies, but regrettably, there are very few people who are fortunate enough to see them this way.

This volume is dedicated to the memory of the eminent carcinologist Michael Turkay, of the Research Institute and Natural History Museum Senckenberg, Frankfurt am Main, Germany. It is a tribute to his outstanding international contribution to the study of decapod crustaceans. An extensive account of Michael's life and achievements is presented, along with thirty-one scientific papers by 62 of his friends and colleagues from around the world. The book's focus is almost entirely on decapod crustaceans, and covers a variety of topics, including taxonomy, systematics, zoogeography, morphology, palaeontology, genetics, general biology and ecology. Numerous new taxa are described from a number of marine and freshwater groups, including one new genus and 13 new species named in honour of Michael himself. The contents of this volume were originally published in 2017 in Crustaceana volume 90, issue 7-10.

This book is a comprehensive introduction to social constructionist ideas and their application within the psychological therapies. Whether you are a trainee or qualified therapist, this book will support you to think about therapy as a socially constructed and relational process, and to develop as a more culturally, socially and politically aware practitioner. It advocates for 'therapist activists' who understand the interplay between the micro and the macro in therapeutic contexts and debunks the idea of the 'isolated client' to examine how broader societal conditions create problems for the individual. Chapters are designed to engage, offering a variety of features to support learning, including: - Introductory and concluding chapter summaries - Textboxes summarising content & spotlighting key information - Case studies and vignettes throughout - Reflective questions & thought-provoking exercises - Recommended Further Reading. This book has wide applicability, with author affiliations across both North and South America - the University of New Hampshire in the US and the Federal University of Uberlandia in Brazil.

This book brings together the latest information on almond genomics and transcriptomics, with a particular focus on cutting-edge findings, tools, and strategies employed in genome sequencing and analysis with regard to the most important agronomic traits. Cultivated almond [(Prunus dulcis (Miller) D. A. Webb, syn. Prunus amygdalus Batsch., Amygdalus communis L., Amygdalus dulcis Mill.)] is a tree crop producing seeds of great economic interest, and adapted to hot and dry climates. Domesticated in Southeast Asia, its small diploid genome and phenotypic diversity make it an ideal model to complement genomics studies on peach, generally considered to be the reference Prunus species. Both represent consanguineous species that evolved in two distinct environments: warmer and more humid in the case of peach, and colder and xerophytic for almond. The advent of affordable whole-genome sequencing, in combination with existing Prunus functional genomics data, has now made it possible to leverage the novel diversity found in almond, providing an unmatched resource for the genetic improvement of this species.

Veteran broadcaster Joe Castiglione has seen his share of heartbreaking games, especially from his vantage point at Fenway Park where he has called the Red Sox games for the last 20 years. In his newest book, Castiglione not only recounts the drama from the booth in Boston, but also his travels and baseball adventures throughout the country in his previous stints with the Cleveland Indians and Milwaukee Brewers over his 30-year career. Special chapters are devoted to favorite players, spring training, major league cities and the business of sports broadcasting.

Quisiera saber quien en este mundo no ha cometido mas de un error en un solo dia. La respuesta es obvia. El problema es que desconocemos que debemos hacer con la energia negativa --sumamente toxica-- que, inevitablemente, se queda dentro de nosotros cuando manejamos incorrectamente nuestras emociones y decisiones en torno a nuestros errores. Este valioso manual no pretende convertirnos en santos, menos aun en personas perfectas, sino que su proposito es mostrarnos como liberarnos del dano y los malestares asociados con los errores que cometemos, siempre con la finalidad de sentirnos mejor con nosotros mismos, crecer, ganar nuevas habilidades y desarrollarnos logrando una mejora continua sin la necesidad de vivir como victimas de nuestras equivocaciones. Durante la lectura de este manual descubriras el dano que nos causa a los seres humanos el temible virus RSP (Reaccionar Sin Pensar) y sabras que hacer para controlarlo. De igual modo, comprenderas que es el sentimiento de culpa y como transformar en energia positiva la energia negativa que inevitablemente lo acompana. Los errores son quiza nuestros mejores aliados, pero lamentablemente existen muy pocas personas con la capacidad de comprenderlo de esa manera.

This book brings together a collection of selected empirical studies by researchers and English for Academic Purposes professionals working with scholars who use English as an additional language and who face barriers to publication when communicating the results of their research in the international context. The contributions have their origins in papers and workshops presented at the conference «Publishing and Presenting Research Internationally: Issues for Speakers of English as an Additional Language (PRISEAL), which took place at the University of La Laguna (Spain) from 11 to 13 January 2007. The various issues which are addressed in this volume are grouped into three main themes: 1. Descriptive studies of linguistic and rhetorical features of written and spoken academic genres. 2. Contrastive studies of academic discourse with a focus on rhetorical preferences of members of scientific communities across cultures, disciplines and genres. 3. Studies which evaluate English for Academic Purposes courses and materials in terms of how successfully they develop the scholar's ability to communicate more effectively in English.

Integrated water resources management advocates a coordinated approach for managing water resources in a way that balances social and economic needs with concern for the environment. While potentially useful, integrated water management is also controversial. Supporters believe that the multi-dimensional nature of water can only be understood and managed from a holistic perspective, while critics often argue that integrated water management lacks suffi ciently well-defi ned rules for its practical implementation. This book, written by academics, users and practitioners, provides a down-to-earth approach to the ideal of integrated water resources management, drawing from conceptual frameworks and real-life practice to identify the key aspects that are yet to be resolved. As such, it examines the role of water accounting, food trade, environmental externalities and intangible values as key aspects whose consideration may help the water management community move forward. Overall, integrated water resources management is perceived to be a useful utopia, whose value lies more in the steps that need to be taken to make it a reality than in achieving its ever-elusive end goal.

Table of Contents

Foreword

About the Water Observatory of the Botín Foundation

SECTION 1

Introduction and international perspectives

1 Integrated Water Resources Management (IWRM): The international experience

M. Ait Kadi

2 Integrated Water Resources Management: State of the art and the way forward

P. Martínez-Santos, M.M. Aldaya & M.R. Llamas

3 Non-Integrated Water Resources Management

M. Giordano & T. Shah

4 Contemporary responses to water management challenges

X. Leflaive

5 Water policy, agricultural trade and WTO rules

L.A. Jackson, C. Pene, M.-B. Martinez-Hommel, C. Hofmann & L. Tamiotti

SECTION 2

Integrated Water Resources Management: Lessons learnt in Spain

6 Virtual water trade, food security and sustainability: Lessons from Latin America and Spain

D. Chico, M.M. Aldaya, I. Flachsbarth & A. Garrido

7 Ten years of the Water Framework Directive in Spain: An overview of the ecological and chemical status of surface water bodies

B.A. Willaarts, M. Ballesteros & N. Hernández-Mora

8 Intensive groundwater use in agriculture and IWRM: An impossible marriage?

L. De Stefano, E. López-Gunn & P. Martínez-Santos

9 Future Institutions? On the evolution in Spanish institutions from policy takers to policy makers

E. López-Gunn, G. Huelva, L. De Stefano & F. Villarroya

10 Urban water, an essential part of Integrated Water Resources Management

E. Cabrera & E. Custodio

SECTION 3

Selected case studies on Integrated Water Resources Management

11 Integrated water resources in Peru – The long road ahead

A.J.M. Kuroiwa, L.F. Castro, M.N. Lucen & J.I. Montenegro

12 Integrated water management in Chile

G. Donoso

13 Towards IWRM in the upper Guadiana basin, Spain

J.Á.R. Cabellos

14 Water resource vulnerability & adaptation management to climate change & human activity in North China

J. Xia

15 Blue water transfer versus virtual water transfer in China – with a focus on the South-North Water Transfer Project

H. Yang, Y. Zhou & J.G. Liu

16 The institutional organization of irrigation in Spain and other Mediterranean countries

L.A.D.R. Thuy, J. Valero de Palma & E. López-Gunn

Index

This book presents a developmental perspective on the psychopathology of offspring of depressed mothers. A primary theme of this study is the interplay of factors in child (developmental stage, gender, temperament) and environment (depressed mother's symptomatic behavior and family functioning) as a key to psychiatric and psychosocial problems in children. This enlightening study closely follows children and their families through every stage of childhood. This book demonstrates just how influential a depressed mother is to the development of her child.

Los conceptos de alteridad e identidad han ocupado en los ultimos anos un espacio central en los debates academicos en torno a la multiculturalidad. Con este libro se pretende hacer una aportacion novedosa al debate uniendo dos tiempos y dos espacios que habitualmente han sido estudiados por separado: el mundo europeo y mediterraneo medieval y el mundo atlantico de comienzos de la modernidad. El trabajo parte de una pregunta fundamental: ?como describe el viajero al otro totalmente desconocido en comparacion al extrano ya conocido o del que al menos se tienen referencias? Este interrogante dara pie a otros que permitiran al lector viajar junto a Bernhard von Breidenbach, Pero Tafur, Hieronymus Munzer, Leo von Rozmital, Jean de Bethencourt, Fernando de Magallanes o Cristobal Colon entre otros.

This astute volume brings together the latest expert research on adamantinomatous craniopharyngiomas (ACPs). ACPs are histologically benign but clinically aggressive tumors exhibiting a high propensity for local invasion into the hypothalamus, optic and vascular structures. These tumors, as well as the current treatments, may result in pan-hypopituitarism, diabetes insipidus, morbid obesity followed by type II diabetes mellitus, blindness, as well as serious behavioral and psychosocial impairments. Exploring in detail advances in both the understanding of tumor biology as well as clinical advances in patient management are explored in detail, this book will also look towards potential new treatment approaches. Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underlie the etiology of the majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke's pouch precursors. In addition, a role for tissue-specific adult pituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have been shown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy.

This volume collects contributions written by different experts in honor of Prof. Jaime Munoz Masque. It covers a wide variety of research topics, from differential geometry to algebra, but particularly focuses on the geometric formulation of variational calculus; geometric mechanics and field theories; symmetries and conservation laws of differential equations, and pseudo-Riemannian geometry of homogeneous spaces. It also discusses algebraic applications to cryptography and number theory. It offers state-of-the-art contributions in the context of current research trends. The final result is a challenging panoramic view of connecting problems that initially appear distant.

The study presented in this book imposes a developmental perspective on the psychopathology of offspring of depressed mothers. A primary theme is the interplay of factors in child (developmental stage, gender, temperament) and environment (depressed mother's symptomatic behaviour and family functioning) as contributors to psychiatric and psychosocial problems in offspring. Children and their families are followed from toddler-hood to the threshold of adulthood. The emergence and evolution of problems differ by mother's diagnosis - unipolar and bipolar depressed as well. Configurations of variables in the individual child are identified which, in combination, create diverse processes that put offspring at risk for specific problems. Early depressed mother-child relationships are strongly influential. Specific affective and temperament qualities of mother and child act reciprocally, increasing. The longitudinal data grasp the nature of connectedness of early experience to ongoing development, and identify patterns of child-to-adult connections. Findings suggest new questions and revised research paradigms.

This book is a comprehensive introduction to social constructionist ideas and their application within the psychological therapies. Whether you are a trainee or qualified therapist, this book will support you to think about therapy as a socially constructed and relational process, and to develop as a more culturally, socially and politically aware practitioner. It advocates for 'therapist activists' who understand the interplay between the micro and the macro in therapeutic contexts and debunks the idea of the 'isolated client' to examine how broader societal conditions create problems for the individual. Chapters are designed to engage, offering a variety of features to support learning, including: - Introductory and concluding chapter summaries - Textboxes summarising content & spotlighting key information - Case studies and vignettes throughout - Reflective questions & thought-provoking exercises - Recommended Further Reading. This book has wide applicability, with author affiliations across both North and South America - the University of New Hampshire in the US and the Federal University of Uberlandia in Brazil.

Growing up in a tiny shack in the Dominican Republic, Felipe Alou never dreamed he would be the first man born and raised in his country to play and manage in Major League Baseball-and also the first to play in the World Series. In this extraordinary autobiography, Alou tells of his real dream to become a doctor, and an improbable turn of events that led to the pro contract. Battling racism in the United States and political turmoil in his home country, Alou persevered, paving the way for his brothers and scores of other Dominicans, including his son Moises. Alou played seventeen years in the Major Leagues, accumulating more than two thousand hits and two hundred home runs, and then managed for another fourteen years-four with the San Francisco Giants and ten with the Montreal Expos, where he became the winningest manager in franchise history. Alou's pioneering journey is embedded in the history of baseball, the Dominican Republic, and a remarkable family.

Integrated water resources management advocates a coordinated approach for managing water resources in a way that balances social and economic needs with concern for the environment. While potentially useful, integrated water management is also controversial. Supporters believe that the multi-dimensional nature of water can only be understood and managed from a holistic perspective, while critics often argue that integrated water management lacks suffi ciently well-defi ned rules for its practical implementation. This book, written by academics, users and practitioners, provides a down-to-earth approach to the ideal of integrated water resources management, drawing from conceptual frameworks and real-life practice to identify the key aspects that are yet to be resolved. As such, it examines the role of water accounting, food trade, environmental externalities and intangible values as key aspects whose consideration may help the water management community move forward. Overall, integrated water resources management is perceived to be a useful utopia, whose value lies more in the steps that need to be taken to make it a reality than in achieving its ever-elusive end goal.

Table of Contents

Foreword

About the Water Observatory of the Botín Foundation

SECTION 1

Introduction and international perspectives

1 Integrated Water Resources Management (IWRM): The international experience

M. Ait Kadi

2 Integrated Water Resources Management: State of the art and the way forward

P. Martínez-Santos, M.M. Aldaya & M.R. Llamas

3 Non-Integrated Water Resources Management

M. Giordano & T. Shah

4 Contemporary responses to water management challenges

X. Leflaive

5 Water policy, agricultural trade and WTO rules

L.A. Jackson, C. Pene, M.-B. Martinez-Hommel, C. Hofmann & L. Tamiotti

SECTION 2

Integrated Water Resources Management: Lessons learnt in Spain

6 Virtual water trade, food security and sustainability: Lessons from Latin America and Spain

D. Chico, M.M. Aldaya, I. Flachsbarth & A. Garrido

7 Ten years of the Water Framework Directive in Spain: An overview of the ecological and chemical status of surface water bodies

B.A. Willaarts, M. Ballesteros & N. Hernández-Mora

8 Intensive groundwater use in agriculture and IWRM: An impossible marriage?

L. De Stefano, E. López-Gunn & P. Martínez-Santos

9 Future Institutions? On the evolution in Spanish institutions from policy takers to policy makers

E. López-Gunn, G. Huelva, L. De Stefano & F. Villarroya

10 Urban water, an essential part of Integrated Water Resources Management

E. Cabrera & E. Custodio

SECTION 3

Selected case studies on Integrated Water Resources Management

11 Integrated water resources in Peru – The long road ahead

A.J.M. Kuroiwa, L.F. Castro, M.N. Lucen & J.I. Montenegro

12 Integrated water management in Chile

G. Donoso

13 Towards IWRM in the upper Guadiana basin, Spain

J.Á.R. Cabellos

14 Water resource vulnerability & adaptation management to climate change & human activity in North China

J. Xia

15 Blue water transfer versus virtual water transfer in China – with a focus on the South-North Water Transfer Project

H. Yang, Y. Zhou & J.G. Liu

16 The institutional organization of irrigation in Spain and other Mediterranean countries

L.A.D.R. Thuy, J. Valero de Palma & E. López-Gunn

Index

Growing up in a tiny shack in the Dominican Republic, Felipe Alou never dreamed he would be the first man born and raised in his country to play and manage in Major League Baseball-and also the first to play in the World Series. In this extraordinary autobiography, Alou tells of his real dream to become a doctor, and an improbable turn of events that led to the pro contract. Battling racism in the United States and political turmoil in his home country, Alou persevered, paving the way for his brothers and scores of other Dominicans, including his son Moises. Alou played seventeen years in the Major Leagues, accumulating more than two thousand hits and two hundred home runs, and then managed for another fourteen years-four with the San Francisco Giants and ten with the Montreal Expos, where he became the winningest manager in franchise history. Alou's pioneering journey is embedded in the history of baseball, the Dominican Republic, and a remarkable family.