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Primary Aldosteronism (PA) is a disease caused by the
overproduction of aldosterone hormone from the adrenal glands. PA
causes hypertension and the majority with this disease are
undiagnosed for PA. There are new insights into this matter by
using biochemistry as well as advanced radiology. In 2011, a
breakthrough in the genetic derangements came, identifying a
mutated potassium channel gene - KCNJ5 - in about 40% of PA with
adenoma. Chapters in this book include a history of the disorder,
epidemiology, genetics derangements, the KCNJ5 mutations and
phenotype and more.
Primary Aldosteronism (PA) is a disease caused by the
overproduction of aldosterone hormone from the adrenal glands. PA
causes hypertension and the majority with this disease are
undiagnosed for PA. There are new insights into this matter by
using biochemistry as well as advanced radiology. In 2011, a
breakthrough in the genetic derangements came, identifying a
mutated potassium channel gene - KCNJ5 - in about 40% of PA with
adenoma. Chapters in this book include a history of the disorder,
epidemiology, genetics derangements, the KCNJ5 mutations and
phenotype and more.
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