The Fifth Crusade represented a cardinal event in early thirteenth-century history, occurring during what was probably the most intensive period of crusading in both Europe and the Holy Land. Following the controversial outcome of the Fourth Crusade in 1204, and the decrees of the Fourth Lateran Council in 1215, Pope Innocent III's reform agenda was set to give momentum to a new crusading effort. Despite the untimely death of Innocent III in 1216, the elaborate organisation and firm crusading framework made it possible for Pope Honorius III to launch and oversee the expedition. The Fifth Crusade marked the last time that a medieval pope would succeed in mounting a full-scale, genuinely international crusade for the recovery of the Holy Land, yet, despite its significance, it has largely been neglected in the historiography. The crusade was much more than just a military campaign, and the present book locates it in the contemporary context for the first time. The Fifth Crusade in Context is of crucial importance not only to better understand the organization and execution of the expedition itself, but also to appreciate its place in the longer history of crusading, as well as the significance of its impact on the medieval world.

The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build. To effectively design and exploit drug delivery systems, the underlying characteristic of a dosage form must be understood--from the characteristics of the individual formulation components, to how they act and interact within the formulation, and finally, to how this formulation responds in different biological environments. To achieve this, there is a wide range of analytical techniques that can be adopted to understand and elucidate the mechanics of drug delivery and drug formulation. Such methods include e.g. spectroscopic analysis, diffractometric analysis, thermal investigations, surface analytical techniques, particle size analysis, rheological techniques, methods to characterize drug stability and release, and biological analysis in appropriate cell and animal models. Whilst each of these methods can encompass a full research area in their own right, formulation scientists must be able to effectively apply these methods to the delivery system they are considering. The information in this book is designed to support researchers in their ability to fully characterize and analyze a range of delivery systems, using an appropriate selection of analytical techniques. Due to its consideration of regulatory approval, this book will also be suitable for industrial researchers both at early stage up to pre-clinical research.

The Fifth Crusade represented a cardinal event in early thirteenth-century history, occurring during what was probably the most intensive period of crusading in both Europe and the Holy Land. Following the controversial outcome of the Fourth Crusade in 1204, and the decrees of the Fourth Lateran Council in 1215, Pope Innocent III's reform agenda was set to give momentum to a new crusading effort. Despite the untimely death of Innocent III in 1216, the elaborate organisation and firm crusading framework made it possible for Pope Honorius III to launch and oversee the expedition. The Fifth Crusade marked the last time that a medieval pope would succeed in mounting a full-scale, genuinely international crusade for the recovery of the Holy Land, yet, despite its significance, it has largely been neglected in the historiography. The crusade was much more than just a military campaign, and the present book locates it in the contemporary context for the first time. The Fifth Crusade in Context is of crucial importance not only to better understand the organization and execution of the expedition itself, but also to appreciate its place in the longer history of crusading, as well as the significance of its impact on the medieval world.

The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build. To effectively design and exploit drug delivery systems, the underlying characteristic of a dosage form must be understood--from the characteristics of the individual formulation components, to how they act and interact within the formulation, and finally, to how this formulation responds in different biological environments. To achieve this, there is a wide range of analytical techniques that can be adopted to understand and elucidate the mechanics of drug delivery and drug formulation. Such methods include e.g. spectroscopic analysis, diffractometric analysis, thermal investigations, surface analytical techniques, particle size analysis, rheological techniques, methods to characterize drug stability and release, and biological analysis in appropriate cell and animal models. Whilst each of these methods can encompass a full research area in their own right, formulation scientists must be able to effectively apply these methods to the delivery system they are considering. The information in this book is designed to support researchers in their ability to fully characterize and analyze a range of delivery systems, using an appropriate selection of analytical techniques. Due to its consideration of regulatory approval, this book will also be suitable for industrial researchers both at early stage up to pre-clinical research.

This "FASTtrack" book systematically reviews important concepts and facts relating to the delivery and targeting of drugs. Relevant examples of delivery systems are given throughout the book with a focus on delivery systems that have actually reached clinical reality.

First published anonymously on January 10, 1776, during the American Revolution; Common Sense was signed "Written by an Englishman," and the pamphlet became an immediate success. In relation to the population of the Colonies at that time, it had the largest sale and circulation of any book in American history. Common Sense presented the American colonists with a powerful argument for independence from British rule at a time when the question of independence was still undecided. Paine wrote and reasoned in a style that common people understood; forgoing the philosophy and Latin references used by Enlightenment era writers, Paine structured Common Sense like a sermon and relied on Biblical references to make his case to the people. Historian Gordon S. Wood described Common Sense as, "the most incendiary and popular pamphlet of the entire revolutionary era."