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The purpose of this volume is to highlight some current areas of
poxvirus research which are likely to be particularly fruitful in
the upcoming few years. The first chapter, by Drs. Condit and
Niles, discusses poxvirus genetics. Work in this area has provided
mutants, produced practical procedures to simplify the manipulation
of viral genes, and generated information about the molecular
architecture and organization of genes characteristic of pox
viruses. One of the most intensively studied regions of the viral
genome is the HindIII D region of vaccinia, in which a combination
of classical and molecular genetic analysis of the region has been
particularly revealing. Within this region are open reading frames,
some of which are expressed early and others late, organized in a
fashion which is now known to be typical of these viruses. Other
studies, related to temperature sensitive, drug resistant, and drug
dependent mutants, are also discussed. Each of the other reviews
included in this volume summarizes areas of research which have
depended heavily on the genetics of the system. The intracellular
site of a poxvirus infection is mostly, if not exclusively, limited
to the cytoplasm which dictates several interesting biological
ramifications. For example, poxvirus transcription must occur in
the cytoplasm, rather than in the nucleus. The virus copes with
this situation by incorporating into the virion the enzymatic
machinery necessary to initiate transcription from input virus.
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