Accounts in Drug Discovery describes recent case studies in medicinal chemistry with a particular emphasis on how the inevitable problems that arise during any project can be surmounted or overcome. The Editors cover a wide range of therapeutic areas and medicinal chemistry strategies, including lead optimization starting from high throughput screening "hits" as well as rational, structure-based design. The chapters include "follow-ons" and "next generation" compounds that aim to improve upon first generation agents. This volume surveys the range of challenges commonly faced by medicinal chemistry researchers, including the optimization of metabolism and pharmacokinetics, toxicology, pharmaceutics and pharmacology, including proof of concept in the clinic for novel biological targets. The case studies include medicinal chemistry stories on recently approved and marketed drugs, but also chronicle "near-misses", i.e., exemplary compounds that may have proceeded well into the clinic but for various reasons did not result in a successful registration. As the vast majority of projects fail prior to registration, much can be learned from such narratives. By sharing a wide range of drug discovery experiences and information across the community of medicinal chemists in both industry and academia, we believe that these accounts will provide insights into the art of medicinal chemistry as it is currently practiced and will help to serve the needs of active medicinal chemists.

Contemporary urbanisation has two faces: global flows of people, money and information, and that of localised social and economic disparities. Recent research has focused on the headlines of global cities as control centres of the world economy, and social and economic shock waves that have raged through cities and regions, but less attention has been paid to the secret life of cities, and the changing nature of everyday life in the wake of such changes.This book challenges current research and policy agendas recommending spatial concentration and relocation as a solution to the problems of environmental sustainability and social dislocation. Instead, this book highlights the key linkages between social and environmental problems, it argues that neither are likely to be resolved with a simple spatial fix. The book draws attention to local contexts of contemporary urbanisation emphasising consideration of policy making from the perspective of the household as a key unit of analysis in identifying links between labour and housing markets, transport and leisure.This book draws upon detailed household interviews about the daily experience of life in a global city. It illustrates the dilemmas and solutions that people routinely find in order to go on in their lives. It shows that these local fixes that are managed at the level of the household work in spite of, and sometimes against, existing policies aimed at sustainability. It concludes that policy making needs to be radically overhauled in order to address the integrated nature of people's everyday lives.

Apparel is one of the oldest and largest export industries in the world. It is also one of the most global industries because most nations produce for the international textile and apparel market. The changing global landscape drives cost volatility, regulatory risk and change in consumer preference. In today's retail landscape, media and advocacy groups have focussed attention on social and environmental issues, as well as new regulatory requirements and stricter legislations. Understanding and managing any risk within the supply chain, particularly ethical and responsible sourcing, has become increasingly critical. This book first gives a systematic introduction to the evolution of SCRM through literature review and discusses the importance of SCRM in the apparel industry. Second, it describes the life cycle of the apparel supply chain and defines the different roles of the value chain in the apparel industry. Thirdly, it identifies the risk factors in the Apparel Life Cycle and analyses the risk sources and consequences and finally, extends the importance of selection of the suppliers and develops a supplier selection model and SCRM strategies solution by data analysis and case studies.

This book constitutes the refereed proceedings of the First International Conference on the Theory and Application of Diagrams, Diagrams 2000, held in Edinburgh, Scotland, UK in September 2000.The 31 revised full papers presented together with 9 posters were carefully reviewed and selected from around 100 submissions. The papers are organized in topical sections on logic and diagrams, theoretical concerns about diagrams, human communication with diagrams, diagrammatic reasoning and proof systems, and diagrams for systems versus systems for diagrams.

Apparel is one of the oldest and largest export industries in the world. It is also one of the most global industries because most nations produce for the international textile and apparel market. The changing global landscape drives cost volatility, regulatory risk and change in consumer preference. In today's retail landscape, media and advocacy groups have focussed attention on social and environmental issues, as well as new regulatory requirements and stricter legislations. Understanding and managing any risk within the supply chain, particularly ethical and responsible sourcing, has become increasingly critical. This book first gives a systematic introduction to the evolution of SCRM through literature review and discusses the importance of SCRM in the apparel industry. Second, it describes the life cycle of the apparel supply chain and defines the different roles of the value chain in the apparel industry. Thirdly, it identifies the risk factors in the Apparel Life Cycle and analyses the risk sources and consequences and finally, extends the importance of selection of the suppliers and develops a supplier selection model and SCRM strategies solution by data analysis and case studies.

Contemporary urbanisation has two faces: global flows of people, money and information, and that of localised social and economic disparities. Recent research has focused on the headlines of global cities as control centres of the world economy, and social and economic shock waves that have raged through cities and regions, but less attention has been paid to the secret life of cities, and the changing nature of everyday life in the wake of such changes.This book challenges current research and policy agendas recommending spatial concentration and relocation as a solution to the problems of environmental sustainability and social dislocation. Instead, this book highlights the key linkages between social and environmental problems, it argues that neither are likely to be resolved with a simple spatial fix. The book draws attention to local contexts of contemporary urbanisation emphasising consideration of policy making from the perspective of the household as a key unit of analysis in identifying links between labour and housing markets, transport and leisure.This book draws upon detailed household interviews about the daily experience of life in a global city. It illustrates the dilemmas and solutions that people routinely find in order to go on in their lives. It shows that these local fixes that are managed at the level of the household work in spite of, and sometimes against, existing policies aimed at sustainability. It concludes that policy making needs to be radically overhauled in order to address the integrated nature of people's everyday lives.