This book constitutes the refereed proceedings of the Second Conference on Creativity in Intelligent Technologies and Data Science, CIT&DS 2017, held in Volgograd, Russia, in September 2017. The 58 revised full papers and two keynote papers presented were carefully reviewed and selected from 194 submissions. The papers are organized in topical sections on Knowledge Discovery in Patent and Open Sources for Creative Tasks; Open Science Semantic Technologies; Computer Vision and Knowledge-Based Control; Pro-Active Modeling in Intelligent Decision Making Support; Data Science in Energy Management and Urban Computing; Design Creativity in CASE/CAI/CAD/PDM; Intelligent Internet of Services and Internet of Things; Data Science in Social Networks Analysis; Creativity and Game-Based Learning; Intelligent Assistive Technologies: Software Design and Application.