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Medicinal chemistry is both science and art. The science of
medicinal chemistry offers mankind one of its best hopes for
improving the quality of life. The art of medicinal chemistry
continues to challenge its practitioners with the need for both
intuition and experience to discover new drugs. Hence sharing the
experience of drug research is uniquely beneficial to the field of
medicinal chemistry. Drug research requires interdisciplinary
team-work at the interface between chemistry, biology and medicine.
Therefore, the topic-related series Topics in Medicinal Chemistry
covers all relevant aspects of drug research, e.g.
pathobiochemistry of diseases, identification and validation of
(emerging) drug targets, structural biology, drugability of
targets, drug design approaches, chemogenomics, synthetic chemistry
including combinatorial methods, bioorganic chemistry, natural
compounds, high-throughput screening, pharmacological in vitro and
in vivo investigations, drug-receptor interactions on the molecular
level, structure-activity relationships, drug absorption,
distribution, metabolism, elimination, toxicology and
pharmacogenomics. In general, special volumes are edited by well
known guest editors.
Medicinal chemistry is both science and art. The science of
medicinal chemistry offers mankind one of its best hopes for
improving the quality of life. The art of medicinal chemistry
continues to challenge its practitioners with the need for both
intuition and experience to discover new drugs. Hence sharing the
experience of drug research is uniquely beneficial to the field of
medicinal chemistry. Drug research requires interdisciplinary
team-work at the interface between chemistry, biology and medicine.
Therefore, the topic-related series Topics in Medicinal Chemistry
covers all relevant aspects of drug research, e.g.
pathobiochemistry of diseases, identification and validation of
(emerging) drug targets, structural biology, drugability of
targets, drug design approaches, chemogenomics, synthetic chemistry
including combinatorial methods, bioorganic chemistry, natural
compounds, high-throughput screening, pharmacological in vitro and
in vivo investigations, drug-receptor interactions on the molecular
level, structure-activity relationships, drug absorption,
distribution, metabolism, elimination, toxicology and
pharmacogenomics. In general, special volumes are edited by well
known guest editors.
The aim of the book is to provide a succinct overview of the
current status of glycoscience from both basic biological and
medical points of view and to propose future directions, in order
to facilitate further integrations of glycoscience with other
fields in biological and medical studies. Glycans (carbohydrate
oligomers) are the so-called "building blocks" of carbohydrates,
nucleic acids, proteins and lipids and play major roles in many
biological phenomena as well as in various pathophysiological
processes. However, this area of glycoscience has been neglected
from the research community because glycan structures are very
complex and functionally diverse and as compared to proteins and
nucleic acids simple tools for the amplification, sequencing and
auto-synthesis of glycans are not available. Many scientists in
other fields of research have now realized that glycosylation, i.e.
the addition of glycans to a protein backbone, is the most abundant
post translational modification reactions and is an important field
of research and sometimes they require a glycobiology and/or
glycochemistry approach to be used. It is still difficult, however,
for non-expert researchers to use these techniques. This book
provides numerous but simple overviews of current topics and
protocols for the experiments. The book is aimed at university
students and above, including non-experts in the field of
glycoscience.
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