Volume II of this two-volume, interdisciplinary work is a unified presentation of a broad range of state-of-the-art topics in the rapidly growing field of mathematical modeling in the biological sciences. Highlighted throughout are mathematical and computational apporaches to examine central problems in the life sciences, ranging from the organization principles of individual cells to the dynamics of large populations. The chapters are thematically organized into the following main areas: epidemiology, evolution and ecology, immunology, neural systems and the brain, and innovative mathematical methods and education.

The work will be an excellent reference text for a broad audience of researchers, practitioners, and advanced students in this rapidly growing field at the intersection of applied mathematics, experimental biology and medicine, computational biology, biochemistry, computer science, and physics.

This IMA Volume in Mathematics and its Applications CLASSICAL AND MODERN BRANCHING PROCESSES is based on the proceedings with the same title and was an integral part of the 1993-94 IMA program on "Emerging Applications of Probability." We would like to thank Krishna B. Athreya and Peter J agers for their hard work in organizing this meeting and in editing the proceedings. We also take this opportunity to thank the National Science Foundation, the Army Research Office, and the National Security Agency, whose financial support made this workshop possible. A vner Friedman Robert Gulliver v PREFACE The IMA workshop on Classical and Modern Branching Processes was held during June 13-171994 as part of the IMA year on Emerging Appli cations of Probability. The organizers of the year long program identified branching processes as one of the active areas in which a workshop should be held. Krish na B. Athreya and Peter Jagers were asked to organize this. The topics covered by the workshop could broadly be divided into the following areas: 1. Tree structures and branching processes; 2. Branching random walks; 3. Measure valued branching processes; 4. Branching with dependence; 5. Large deviations in branching processes; 6. Classical branching processes."

This IMA Volume in Mathematics and its Applications CLASSICAL AND MODERN BRANCHING PROCESSES is based on the proceedings with the same title and was an integral part of the 1993-94 IMA program on "Emerging Applications of Probability." We would like to thank Krishna B. Athreya and Peter J agers for their hard work in organizing this meeting and in editing the proceedings. We also take this opportunity to thank the National Science Foundation, the Army Research Office, and the National Security Agency, whose financial support made this workshop possible. A vner Friedman Robert Gulliver v PREFACE The IMA workshop on Classical and Modern Branching Processes was held during June 13-171994 as part of the IMA year on Emerging Appli cations of Probability. The organizers of the year long program identified branching processes as one of the active areas in which a workshop should be held. Krish na B. Athreya and Peter Jagers were asked to organize this. The topics covered by the workshop could broadly be divided into the following areas: 1. Tree structures and branching processes; 2. Branching random walks; 3. Measure valued branching processes; 4. Branching with dependence; 5. Large deviations in branching processes; 6. Classical branching processes."

Biology takes a special place among the other natural sciences because biological units, be they pieces of DNA, cells or organisms, reproduce more or less faithfully. As for any other biological processes, reproduction has a large random component. The theory of branching processes was developed especially as a mathematical counterpart to this most fundamental of biological processes. This active and rich research area allows us to make predictions about both extinction risks and the development of population composition, and also uncovers aspects of a population's history from its current genetic composition. Branching processes play an increasingly important role in models of genetics, molecular biology, microbiology, ecology and evolutionary theory. This book presents this body of mathematical ideas for a biological audience, but should also be enjoyable to mathematicians.

Biology takes a special place among the other natural sciences because biological units, be they pieces of DNA, cells or organisms, reproduce more or less faithfully. As for any other biological processes, reproduction has a large random component. The theory of branching processes was developed especially as a mathematical counterpart to this most fundamental of biological processes. This active and rich research area allows us to make predictions about both extinction risks and the development of population composition, and also uncovers aspects of a population's history from its current genetic composition. Branching processes play an increasingly important role in models of genetics, molecular biology, microbiology, ecology and evolutionary theory. This book presents this body of mathematical ideas for a biological audience, but should also be enjoyable to mathematicians.