Chronic overconsumption of sugar and fat elevates plasma levels of insulin and free fatty acids, a process referred to as glucolipotoxicity. This phenomenon may lead to heart failure. This issue explores in depth the relationship between glucolipotoxicity and heart failure.

Diabetes mellitus has become epidemic on a global scale, and millions of new cases are diagnosed every year. The epidemic of diabetes mellitus is expected to result in one of the steepest rises in human morbidity and mortality ever observed outside of wartime. Insulin resistance is a hallmark of pre-diabetes and type 2 diabetes mellitus, and is characterized by impaired insulin- signaling transduction. Authoritative and comprehensive, Lipoproteins in Diabetes Mellitus details the many changes wrought by insulin resistance and diabetes mellitus on lipid and lipoprotein metabolism. The book begins by summarizing the various techniques to measure lipoproteins and their subclasses. The mechanisms by which insulin resistance and diabetes mellitus increase risk for atherosclerosis, diabetic retinopathy, and diabetic nephropathy are then explored in detail. Finally, the effects of lifestyle modification and the results of clinical trials using established and investigational drugs are discussed. An invaluable contribution to the literature, Lipoproteins in Diabetes Mellitus is a comprehensive reference on the clinical and scientific aspects of lipoproteins in diabetes. It will have a long-lasting and significant effect on the medical management of people with diabetes.

Filling a large gap in the literature, this book focuses on the management of patients who have, or are at risk of developing, cardiovascular disease. Designed to serve as a resource for the busy, practicing clinician, the approach is evidence-based but practical. Conceptual development and the exploration of biochemical and physiological mechanisms are balanced by focused attention on the everyday issues of caring for patients with specific metabolic and cardiovascular disorders. Reinforced by case studies, the book discusses standards of care and challenging management issues. The authors discuss pharmacotherapeutic choices in light of findings from clinical trials, elements of care unique to women and people of different racial and ethnic groups, lifestyle modifications, and the risks and benefits of specific therapies. The book reviews comprehensive care in both primary and secondary prevention settings. Moreover, Comprehensive Management of High Risk Cardiovascular Patients encourages primary care providers to get more involved in treating such disorders as atherosclerotic disease, congestive heart failure, severe hypertension, complex dyslipidemias, and chronic renal disease, among others.

* Provides practical knowledge and comprehensive coverage of cardiovascular disease Is written with the aim to improve the quality of care Presents contributions from nationally and internationally acknowledged experts in their respective fields Includes algorithms, case studies, and recommendations on evidence-based practice in each chapter Designed to help the busy practitioner perform assessments, initiate and guide efficacious therapy, and know when referral to a cardiologist is advisable Comprehensive Cardiovascular Medicine in the Primary Care Setting provides an authoritative, detailed discussion of cardiovascular disease balanced with practical utility. Disease states are explained with emphasis on risk factors, risk estimation, and established cardiac disease. The book also delves into the co-morbid conditions which surround cardiovascular disease, including peripheral vascular disease, chronic kidney disease, depression, and erectile dysfunction, with the goal of improving quality of life for affected individuals. An abundance of algorithms, case studies, and recommendations on evidence-based best practices facilitate rapid learning. A key resource for the busy practitioner, this book is designed to give the reader the skills to confidently perform assessments, initiate and maintain efficacious therapy, and know when a referral to a cardiologist is advisable.

The thoroughly updated second edition of this key textbook provides an authoritative discussion of cardiovascular disease for the practicing primary care clinician. It examines a variety of disease states with emphasis on risk factors, risk estimation, and established cardiac disease. The book also explores the co-morbid conditions that surround cardiovascular disease. It includes key points, algorithms, case studies, recommendations on evidence-based practice, and summary boxes. A key resource for the busy practitioner, the Second Edition of Comprehensive Cardiovascular Medicine in the Primary Care Setting is designed to give residents, fellows, and primary care physicians the skills to confidently perform assessments, initiate and maintain efficacious therapy, and know when a referral to a cardiologist is advisable.

This reference will serve as a stimulus to the reader to continue to learn about the ever changing and fascinating field of therapeutic lipidology. It will also empower readers to improve and extend the lives of the patients they so conscientiously serve.