Metabolic engineering has been developed over the past 20 years to become an important tool for the rational engineering of industrial microorganisms. This book has a particular interest in the methods and applications of metabolic engineering to improve the production and yield of a variety of different metabolites. The overall goal is to achieve a better understanding of the metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production.

Lipids are functionally versatile molecules. They have evolved from relatively simple hydrocarbons that serve as depot storages of metabolites and barriers to the permeation of solutes into complex compounds that perform a variety of signalling functions in higher organisms. This volume is devoted to the polar lipids and their constituents. We have omitted the neutral lipids like fats and oils because their function is generally to act as deposits of metabolizable substrates. The sterols are also outside the scope of the present volume and the reader is referred to volume 28 of this series which is the subject of cholesterol. The polar lipids are comprised of fatty acids attached to either glycerol or sphingosine. The fatty acids themselves constitute an important reservoir of substrates for conversion into families of signalling and modulating molecules including the eicosanoids amongst which are the prostaglandins, thromboxanes and leucotrienes. The way fatty acid metabolism is regulated in the liver and how fatty acids are desaturated are subjects considered in the first part of this volume. This section also deals with the modulation of protein function and inflammation by unsaturated fatty acids and their derivatives. New insights into the role of fatty acid synthesis and eicosenoid function in tumour progression and metastasis are presented.

In his inimitable prose, master storyteller Peter Quinn chronicles his odyssey from the Irish Catholic precincts of the Bronx to the arena of big-league politics and corporate hardball. Cross Bronx is Peter Quinn’s one-of-a-kind account of his adventures as ad man, archivist, teacher, Wall Street messenger, court officer, political speechwriter, corporate scribe, and award-winning novelist. Like Pete Hamill, Quinn is a New Yorker through and through. His evolution from a childhood in a now-vanished Bronx, to his exploits in the halls of Albany and swish corporate offices, to then walking away from it all, is evocative and entertaining and enlightening from first page to last. Cross Bronx is bursting with witty, captivating stories. Quinn is best known for his novels (all recently reissued by Fordham University Press under its New York ReLit imprint), most notably his American Book Award–winning novel Banished Children of Eve. Colum McCann has summed up Quinn’s trilogy of historical detective novels as “generous and agile and profound.” Quinn has now seized the time and inspiration afforded by “the strange interlude of the pandemic” to give his up-close-and-personal accounts of working as a speechwriter in political backrooms and corporate boardrooms: “In a moment of upended expectations and fear-prone uncertainty, the tolling of John Donne’s bells becomes perhaps not as faint as it once seemed. Before judgment is pronounced and sentence carried out, I want my chance to speak from the dock. Let no man write my epitaph. In the end, this is the best I could do.” (from the Prologue) From 1979 to 1985 Quinn worked as chief speechwriter for New York Governors Hugh Carey and Mario Cuomo, helping craft Cuomo’s landmark speech at the 1984 Democratic Convention and his address on religion and politics at Notre Dame University. Quinn then joined Time Inc. as chief speechwriter and retired as corporate editorial director for Time Warner at the end of 2007. As eyewitness and participant, he survived elections, mega-mergers, and urban ruin. In Cross Bronx he provides his insider’s view of high-powered politics and high-stakes corporate intrigue. Incapable of writing a dull sentence, the award-winning author grabs our attention and keeps us enthralled from start to finish. Never have his skills as a storyteller been on better display than in this revealing, gripping memoir.

Metabolic engineering has been developed over the past 20 years to become an important tool for the rational engineering of industrial microorganisms. This book has a particular interest in the methods and applications of metabolic engineering to improve the production and yield of a variety of different metabolites. The overall goal is to achieve a better understanding of the metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production.

Bohernabreena is one of the most fascinating and historic areas in all of Ireland. Including the settlements of the Glenasmole Valley, the legend of Tir na nOg, and the megalithic burial chamber on Seefin Mountain, this book takes the reader on a journey through the past of Ireland itself. Alongside being a window into our national identity, Bohernabreena is also a beautiful and historic area in its own right, and in this illustrated history Peter Quinn has created a vibrant and valuable record for all those with an interest in its development.