This book constitutes the refereed proceedings of the 18th International Symposium on Methodologies for Intelligent Systems, ISMIS 2009, held in Prague, Czech Republic, in September 2009.

The 60 revised papers presented together with 4 plenary talks were carefully reviewed and selected from over 111 submissions. The papers are organized in topical sections on knowledge discovery and data mining, applications and intelligent systems in Medicine, logical and theoretical aspects of intelligent systems, text mining, applications of intelligent sysems in music, information processing, agents, machine learning, applications of intelligent systems, complex data, general AI as well as uncertainty.

The healthcare industry produces a constant flow of data, creating a need for deep analysis of databases through data mining tools and techniques resulting in expanded medical research, diagnosis, and treatment. ""Data Mining and Medical Knowledge Management: Cases and Applications"" presents case studies on applications of various modern data mining methods in several important areas of medicine, covering classical data mining methods, elaborated approaches related to mining in electroencephalogram and electrocardiogram data, and methods related to mining in genetic data. A premier resource for those involved in data mining and medical knowledge management, this book tackles ethical issues related to cost-sensitive learning in medicine and produces theoretical contributions concerning general problems of data, information, knowledge, and ontologies.