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This book discusses specific immune cell regulatory pathway(s),
immune cell types, or other mechanisms involved in host responses
to tuberculosis that can be potentially targeted for host-directed
therapy (HDT). The pathways/mechanisms investigated are either
protective - thus calling for pathway/factor enhancing drugs - or
maladaptive - thus calling for pathway/factor inhibitory drugs.
Discovery and development (pre-clinical and clinical) of candidate
HDT agents will also be elucidated, as well as approaches for HDT
of other diseases. The benefit to the reader will derive from
learning about the biology of multiple host pathways involved in
health and disease, how these pathways are disrupted or
dysregulated during tuberculosis, and which druggable targets exist
in these pathways. This book provides the reader with a roadmap of
current and future directions of HDT against tuberculosis. Since
the host pathways/factors involved in protective or maladaptive
responses to tuberculosis are not disease-specific, information
learned from the context of tuberculosis likely will be relevant to
other infectious and non-infectious diseases.
This book discusses specific immune cell regulatory pathway(s),
immune cell types, or other mechanisms involved in host responses
to tuberculosis that can be potentially targeted for host-directed
therapy (HDT). The pathways/mechanisms investigated are either
protective - thus calling for pathway/factor enhancing drugs - or
maladaptive - thus calling for pathway/factor inhibitory drugs.
Discovery and development (pre-clinical and clinical) of candidate
HDT agents will also be elucidated, as well as approaches for HDT
of other diseases. The benefit to the reader will derive from
learning about the biology of multiple host pathways involved in
health and disease, how these pathways are disrupted or
dysregulated during tuberculosis, and which druggable targets exist
in these pathways. This book provides the reader with a roadmap of
current and future directions of HDT against tuberculosis. Since
the host pathways/factors involved in protective or maladaptive
responses to tuberculosis are not disease-specific, information
learned from the context of tuberculosis likely will be relevant to
other infectious and non-infectious diseases.
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