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The last decade has witnessed rapid progress in our under standing
of the mechanisms of protein export and secretion in both
prokaryotic and eukaryotic cells. Studies of protein secretion
across the membranes of the rough endoplasmic reticulum have led to
the formulation of the now-classic signal hypothesis, which has
stimulated many discussions and new ideas, and the identification
of the signal recogni tion particle as an organelle in the
initiation of the export process. However, more recent work
pertaining to intrage nic information related to targeting specific
proteins for either secretion or membrane localization, the
energetics of protein secretion, the timing of synthesis versus the
initia tion of export, structural requirements for the processing
of precursor proteins, and the identification of the proces sing
enzymes (signal peptidases), has been the result of a combined
biochemical and genetic approach to the study of protein
localization in bacteria. While reviews on the biochemistry and
genetics of pro tein secretion have appeared frequently in recent
years, this book attempts to summarize the current status and the
future perspectives of this rapidly moving field in a single
volume. Topics covered in this book include the genetics of protein
secretion in E. coli, biochemical analysis of pro tein export in
vitro, signal peptidases, excretion of colicins and hemolysin in E.
coli, protein secretion in Bacillus, and protein secretion cloning
vectors."
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