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This award-winning thesis investigates the mechanisms underlying
cardiac arrhythmia development and termination from an entirely new
perspective. By viewing the heart as a complex system, the author
uses theoretical tools from nonlinear dynamics combined with
numerical simulations and experiments to achieve insights into the
relationship between its structure and dynamics, thereby paving the
way towards innovative low-energy defibrillation strategies. The
work tackles, among other things: the effect of substrate
heterogeneity on the spatial-temporal dynamics of cardiac
arrhythmias and ways in which weak pulsed electric fields can be
used to control these dynamics in heterogeneous cardiac tissue. The
long-term vision of this research is to replace the current
strategy of applying painful and sometimes tissue damaging electric
shock - currently the only reliable way to terminate
life-threatening fibrillation - by a more subtle but equally
effective intervention. The book maps out a number of promising
research directions for biophysicists and medical researchers
working on the origins and treatment of cardiac arrhythmias.
This award-winning thesis investigates the mechanisms underlying
cardiac arrhythmia development and termination from an entirely new
perspective. By viewing the heart as a complex system, the author
uses theoretical tools from nonlinear dynamics combined with
numerical simulations and experiments to achieve insights into the
relationship between its structure and dynamics, thereby paving the
way towards innovative low-energy defibrillation strategies. The
work tackles, among other things: the effect of substrate
heterogeneity on the spatial-temporal dynamics of cardiac
arrhythmias and ways in which weak pulsed electric fields can be
used to control these dynamics in heterogeneous cardiac tissue. The
long-term vision of this research is to replace the current
strategy of applying painful and sometimes tissue damaging electric
shock – currently the only reliable way to terminate
life-threatening fibrillation – by a more subtle but equally
effective intervention. The book maps out a number of promising
research directions for biophysicists and medical researchers
working on the origins and treatment of cardiac arrhythmias.
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