This authoritative and comprehensive 1996 publication looks in depth at a range of medical syndromes characterised by serious and unpredicted internal overheating of the body. These episodes may arise suddenly and unexpectedly in certain individuals, with life-threatening consequences, either as a result of heat stress, exceptional physical exertion or in response to certain common anaesthetics and some drugs, including ecstasy. The chapters focus on the full range of these syndromes, their metabolic and physiological basis, the important pre-disposing factors for the prediction of those at risk, and the medical management of these conditions. The volume includes important contributions from authors of international repute and incorporates a wealth of information from the Leeds malignant hyperthermia investigation unit. This compilation will be of interest to those wanting to understand these disorders.

This definitive resource from the eminent Oxford Textbooks series, the Oxford Textbook of Anaesthesia addresses the fundamental principles, underpinning sciences and the full spectrum of clinical practice. It brings together the most pertinent research from on-going scientific endeavours with practical guidance and a passion to provide the very best clinical care to patients. This comprehensive work covers all aspects of anaesthesia; volume one addresses the fundamental principles and the basic sciences whose understanding is required for a logical, effective and evidence-based approach to practice. Volume two focuses on the clinical aspects of anaesthesia, including those aspects of intensive care and pain medicine that are required by all general anaesthetists as well as sections dedicated to procedures, surgical specialities, paediatrics, the conduct of anaesthesia outside the theatre, and concurrent disease. In 91 finely crafted and highly illustrated chapters, experts in anaesthesia review the supporting evidence and key techniques for the clinical management of specific conditions and patient groups. International contributors share their research and extensive experience to provide a wealth of practical advice for use in clinical situations in a global context. This essential reference tool supports all anaesthetists seeking an up-to-date and trustworthy account of all aspects of anaesthesia, ideal for reference, study and revision. It will be an indispensable guide to anaesthetists of all grades and subspecialty interest.

This authoritative and comprehensive 1996 publication looks in depth at a range of medical syndromes characterised by serious and unpredicted internal overheating of the body. These episodes may arise suddenly and unexpectedly in certain individuals, with life-threatening consequences, either as a result of heat stress, exceptional physical exertion or in response to certain common anaesthetics and some drugs, including ecstasy. The chapters focus on the full range of these syndromes, their metabolic and physiological basis, the important pre-disposing factors for the prediction of those at risk, and the medical management of these conditions. The volume includes important contributions from authors of international repute and incorporates a wealth of information from the Leeds malignant hyperthermia investigation unit. This compilation will be of interest to those wanting to understand these disorders.