This volume aims to extract and summarize all information about CAK by pointing out commonly accepted facts and unresolved issues. It takes the reader from yeast to mammals and describes all areas that CAK is thought to be involved in. This volume is designed to serve newcomers to the field as well as specialists; any person interested in cell growth, signal transduction and cancer will find this a useful tool to own.

The cell cycle is tightly regulated on many different levels to ensure properly controlled proliferation. Deregulation of cell cycle regulation is a hallmark of cancer. In this book, many aspects of cell cycle regulation are discussed, which include G1, S, M phase control, ubiquitin-mediated degradation, DNA damage response, mitotic spindle checkpoint, the centrosome cycle, Retinoblastoma protein family, the Myc oncogene, and mouse models for tumor suppressors, cyclin-dependent kinases, and meiosis. These chapters written by experts provide an updated view on how the cell cycle is regulated in vivo and about the involvement of cell cycle regulators in cancer.