Stem cells are the building blocks of the body. They can develop into any of the cells that make up our bodies. Stem cells carry a lot of hope for the treatment of a broad range of diseases and injuries, spanning from cancers, diabetes, genetic diseases, graft-versus-host disease, eye, heart and liver diseases, inflammatory and auto-immune disorders, to neurological diseases and injuries, particularly neurodegenerative diseases, like Alzheimer's and Parkinson's diseases, cerebral strokes, and traumatic brain and spinal cord injuries. Stem cell research is therefore as important for our understanding the physio- and pathology of the body, as for development and therapy, including for the nervous system. This book aims at providing an overview and in depth analysis of recent developments in stem cell research and therapy. It is composed of recently published review articles that went through a peer-review process.

Stem cells are the building blocks of the body. They can develop into any of the cells that make up our bodies. Stem cells carry a lot of hope for the treatment of a broad range of diseases and injuries, spanning from cancers, diabetes, genetic diseases, graft-versus-host disease, eye, heart and liver diseases, inflammatory and autoimmune disorders, to neurological diseases and injuries, particularly neurodegenerative diseases, like Alzheimer's and Parkinson's diseases, cerebral strokes, and traumatic brain and spinal cord injuries. Stem cell research is therefore as important for understanding the Physio- and pathology of the body as for development and therapy as well as for understanding the nervous system. This book provides an overview and in-depth analysis of recent developments in stem cell research and therapy.

This book aims at providing an overview and in depth analysis of recent developments in stem cell research and therapy. It is composed of recently published review articles that went through peer-review process. Stem cells are the building blocks of the body. They can develop into any of the cells that make up our bodies. Stem cells hold a great deal of hope for the treatment of a broad range of diseases and injuries, spanning from cancers, diabetes, genetic diseases, graft-versus-host disease, eye, heart and liver diseases, inflammatory and autoimmune disorders, to neurological diseases and injuries, particularly neurodegenerative diseases. These include Alzheimer's and Parkinson's diseases, cerebral strokes, and traumatic brain and spinal cord injuries. Therefore, Stem cell research is as important for the understanding of the physio- and pathology of the body, as well as for the development and therapy, including the nervous system. Volume IV provides an overview and in depth analysis of recent developments on the role and functions of newly generated neuronal cells of the adult brain in the physio- and pathology of the nervous system. It further emphasises the tremendous potential of adult neural stem cells, as a promising model, for cellular therapy and regenerative medicine.

The subject of this book is stem cell research and regenerative medicine. Stem cells are undifferentiated cells that have the ability to differentiate into different lineages of the body. Stem cells carry tremendous potential for the treatment of a broad range of disease and injuries. Stem cells exist in embryonic, fetal, and adult tissues, including the adult central nervous system. This book aims at, in depth, the recent developments in stem cell research and regenerative medicine. Though this book encompasses all the fields of stem cell research and regenerative medicine, it emphasises adult neurogenesis and neural stem cell research and therapy.

Stem cells are the building blocks of the body and can develop into any of the cells that make up our bodies. Stem cells carry a lot of hope for the treatment of a broad range of diseases and injuries, spanning from cancers, diabetes, genetic diseases, graft-versus-host disease, eye, heart and liver diseases, inflammatory and autoimmune disorders, to neurological diseases and injuries, particularly neurodegenerative diseases, like Alzheimer's and Parkinson's disease and many others. This book provides an overview and in-depth analysis of recent developments in stem cell research and therapy. It is composed of recently published review articles that went through a peer-review process.

Stem cells are the building blocks of the body. They can develop into any of the cell types that make up our bodies. During development, they contribute to the formation of the tissues. In the adult, they contribute to homeostasis of the tissues and regeneration after injury. Stem cells carry a lot of hope for the treatment of a broad range of diseases and injuries, spanning from neurological diseases and injuries, like Alzheimer's disease, Parkinson's disease and spinal cord injuries, to diabetes, genetic diseases, graft-versus-host diseases, eye, heart and liver diseases, inflammatory and autoimmune disorders, and cancers. Stem cell research is therefore as important for our understanding of development, physio- and pathology of the body, as for therapy. 'Stem Cells' aims at providing an overview and in depth analysis of recent developments in stem cell research and therapy. It is composed of recently published review articles that encompass the field of stem cell research and regenerative medicine. All the articles went through peer-review process.

This book aims at presenting an overview of the current knowledge of cystatins and molecules of the cystatin superfamily, their structure, physio-and pathological function as well as the direction that research is currently aiming for in developing therapeutic treatments based on cysteine proteinases and related molecules. Its purpose is to give the reader a tool that serves as a reference in the field of protease inhibitor, their physio-and pathological functions and therapeutic potential. It also aims at making accessible to a broader audience, that does not have easy access to scientific publications, a source of knowledge and information. To achieve this goal, the book aims at covering broadly, systematically, concisely, and in depth, the multifacets of the role of cystatins and molecules of the cystatin superfamily in physiopathology, and emphasise on their therapeutic potentials. Figures, self-explanatory schemas and diagrams contribute to clarify and support the data presented.

Stem cells are the building blocks of the body. Stem cells carry a lot of hope for the treatment of a broad range of diseases and injuries, spanning from cancers, diabetes, genetic diseases, graft-versus-host disease, eye, heart and liver diseases, inflammatory and auto-immune disorders, to neurological diseases and injuries, particularly neurodegenerative diseases, cerebral strokes, and traumatic brain and spinal cord injuries. Therefore, stem cell research is as important for our understanding the physio- and pathology of the body, as it is for understanding of development and therapy, including for the nervous system. This book provides an overview and in-depth analysis of recent developments in stem cell research and therapy.

This book aims at providing an overview and in depth analysis of recent developments in stem cell research and therapy. It is composed of recently published review articles that went through peer-review process. Stem cells are the building blocks of the body. They can develop into any of the cells that make up our bodies. Stem cells hold a great deal of hope for the treatment of a broad range of diseases and injuries, spanning from cancers, diabetes, genetic diseases, graft-versus-host disease, eye, heart and liver diseases, inflammatory and autoimmune disorders, to neurological diseases and injuries. These include neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, cerebral strokes, and traumatic brain and spinal cord injuries. Therefore, Stem cell research is as important for understanding of the physio- and pathology of the body, as for development and therapy, including the nervous system. Volume V provides an overview and in depth analysis of recent developments in the front of patent applications filed and clinical trials initiated in the field of stem cells, in the aim of introducing stem cell research into therapy.

Over the past-decade or so, studies have revealed and confirmed that new nerve cells are generated in the adult brain of mammals, including humans. These new nerve cells originate from cells, referred as neural stem cells. Neural stem cells have the capacity to generate nerve cells and repair the brain. Hence, contrary to a long-held dogma, neural stem cells reside in the adult brain and therefore the adult brain has the capacity of, and may be amenable to, repair. Adult neurogenesis and neural stem cells offer new avenues and opportunities for the treatment and cure of a broad range of neurological diseases, disorders and injuries. Neural stem cells and cellular therapy aims at providing an overview and in depth analysis of recent developments in neuralstem cell research and therapy. This book is composed of recently published review articles that went through the peer-review process.

The hippocampus , the Greek word for seahorse, is one of the most fascinating and intriguing regions of the mammalian brain. It is a bilateral incurved seahorse-shaped structure of the cerebral cortex. The hippocampus has a highly distinctive morphology. It is composed of two regions, the dentate gyrus (DG) and the Cornu Ammonis (CA). The nerve cells of the main layer of the DG and CA regions, the granule cells and pyramidal cells respectively, are organised in a tri-synaptic lamellaire circuit. The granule and pyramidal cells are glutamatergic excitatory. The granule cells elicit unique histological, biochemical, developmental, physio- and pathological features. The hippocampus is also an area of the brain that elicits a high degree of plasticity, like synaptic and phenotypic plasticity. It is also one of the few regions of the brain where neurogenesis, the generation of new nerve cells, occurs throughout adulthood. The hippocampus is involved in physio-and pathological processes, like learning and memory.

This title contains a book and CD. The brain has a number of nerve cells estimated at a magnitude of 10 to 100 billion, and 1014 to 1015 synapses, and therefore is the most complex organ of the human body. During fetal development the foundations of the brain are laid as billions of neurons form appropriate connections and patterns. In the adult mammalian brain, most neurons are post-mitotic, and therefore at risk for irreversible damage. As we age, atrophy of the brain occurs. As brain weight declines the volume of the brain in the 8th decade is reduced by 6 per cent -10 per cent versus the third decade, and neuronal loss occurs, up to 10,000 to 100,000 neurons are lost per day, though this estimation is being revised downward with the advance of more sophisticated measurements.