This book is a compilation of research papers and presentations from the Fourth Annual International Conference on Data Science, Machine Learning and Blockchain Technology (AICDMB 2023, Mysuru, India, 16-17 March 2023). The book covers a wide range of topics, including data mining, natural language processing, deep learning, computer vision, big data analytics, cryptography, smart contracts, decentralized applications, and blockchain-based solutions for various industries such as healthcare, finance, and supply chain management. The research papers presented in this book highlight the latest advancements and practical applications in data science, machine learning, and blockchain technology, and provide insights into the future direction of these fields. The book serves as a valuable resource for researchers, students, and professionals in the areas of data science, machine learning, and blockchain technology.