The present study focuses on multi target inhibitors search based on proteins of Trypanothione pathway. For this we had modelled TryS, TryR and TryP proteins using Homology modelling and validated, based on which docking calculations were done. In the next step, active sites were explored to allow compounds to dock. Finally, we screened common hits amongst these protein targets. Top compounds were validated and their ADME profiles were also predicted. Some ligands shown good Glide Gscore in all three protein Targets. Interaction profiles can be further utilized to build computational novel structures. The further work needed to fit the hits molecules in assays to validate hits and refine or optimize the hit molecules.

Visceral leishmaniasis or kala-azar remains a major cause of mortality, particularly in the developing world. Remote sensing (RS) and GIS has a role to play in the detection and identification of areas of elevated risk, or associations between disease incidence and social and environmental factors. The work presented in this book inevitably represents only a partial picture of the reciprocal application of RS and GIS capabilities to control visceral leishmaniasis that threaten the global community, with emphasis given to the countries within the India.