|
Showing 1 - 2 of
2 matches in All Departments
Hot Melt Extrusion can be simply defined as the process of forming
a new material by forcing it through an orifice or die under
controlled conditions, such as temperature, mixing, feed-rate and
pressure. Hot Melt Extrusion is the process of embedding drug in a
polymeric carrier. Hot Melt Extrusion is the process of converting
a raw material into a product of uniform shape and density by
forcing it through a die under controlled conditions. In recent
years, interest in hot melt extrusion techniques for pharmaceutical
applications has grown significantly. Hot melt extrusion (HME) is
an established manufacturing process that has been used in the
plastics and food industry since the 1930s. It was first developed
in the early 20th century by the plastics industry as a means of
producing different shapes for a variety of industrial and domestic
applications.
After oral administration, the majority of drug molecules are
absorbed across the small intestine and enter the systemic
circulation via the portal vein and the liver. For some highly
lipophilic drugs (typically log PN5, lipid solubility 50 mg/g),
however, association with lymph lipoproteins in the enterocyte
leads to transport to the systemic circulation via the intestinal
lymph. The attendant delivery benefits associated with lymphatic
drug transport include a reduction in first pass metabolism and
lymphatic exposure to drug concentrations orders of magnitude
higher than that attained in systemic blood. In the current review
we briefly describe the mechanisms by which drug molecules access
the lymph and the formulation strategies that may be utilised to
enhance lymphatic drug transport. Specific focus is directed toward
recent advances in understanding regarding the impact of lipid
source (both endogenous and exogenous) and intracellular lipid
trafficking pathways on lymphatic drug transport and enterocyte
based first pass metabolism.
|
You may like...
Loot
Nadine Gordimer
Paperback
(2)
R398
R330
Discovery Miles 3 300
Personal Shopper
Kristen Stewart, Nora von Waldstätten, …
DVD
R86
Discovery Miles 860
|
Email address subscribed successfully.
A activation email has been sent to you.
Please click the link in that email to activate your subscription.