Covering the latest advances in CNS drug development, this book will guide all those involved in pre-clinical to early clinical trials. The authors describe how recent innovations can accelerate the development of novel CNS compounds, improve early detection of efficacy and toxicity signals, and increase the safety of later-stage clinical trials.

The current crisis in the drug development industry is critically reviewed, as well as the steps needed to correct the problems, including new government-backed regulations and industry-based innovations designed to accelerate CNS drug development in the future.

Animal-based models of major CNS disorders are described in detail, and the ability of the latest in vitro and computer-based models to simulate CNS disease states and predict drug efficacy and side-effects are examined. Particular attention is given to the growing use of biomarkers and how they can be used effectively in early human trials as signals of potential drug efficacy, as well as the increasingly important role of imaging studies to guide dose selection. Cognitive assessments that can be useful indicators of effect in patient populations are also discussed.

Written by a team of clinical scientists involved in CNS drug trials for over 20 years, and based on a wealth of drug development and clinical trial experience, "Critical Pathways to Success in CNS Drug Development"is full of practical advice for successfully designing and executing CNS drug trials, avoiding potential pitfalls, and complying with government regulations

Exciting papers by leading researchers are integrated in this volume with presentations having direct clinical relevance: thus, the latest scientific advances in aging research are coupled with reports on how these advances are being applied to longevity medicine.

Topics include oxidative stress, genetic/biochemical mechanisms, hormone therapy, nutrition, fitness, and exercise, all as they pertain to aging.

In exploring the links between the latest basic gerontological research and the practice of longevity medicine, the current challenges faced by both scientists and clinicians engaged in combating aging and its consequences are presented here. This volume is readily accessible to the educated reader who is interested in learning more about how to reduce the negative impact of aging on human health and longevity.

"NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit" "www.blackwellpublishing.com/nyas".""

"ACADEMY MEMBERS Please contact the New York Academy of Sciences directly to place your order (""www.nyas.org""). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http: //www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member."

For the first time since the 1920s, The Laughing Desert presents the 1925-1926 Salome Sun by Arizona humorist and the "Sage of Salome," Dick Wick Hall. These thirty-two issues of the nationally syndicated weekly newspaper are packed with stories, poems, down home philosophy and Claude G. ("Put") Putnam's illustrations that made the town of Salome famous. Hall poked fun at bankers, Wall Street, all forms of pretension, and even himself. This book also includes previously unpublished photos of Salome and the Hall family, love poems from Dick to his wife, Daysie Sutton Hall, plus images of Arizona's McMullen Valley in the 1920s. Hall's granddaughter, educator and historian Robin R. Cutler, created The Laughing Desert for Arizona's Centennial. Her introduction places the engaging newspaper in its historical context and she includes an epilogue about her grandfather's enduring legacy. Marshall Trimble, Arizona's Official State Historian and a prolific author, educator and sought-after entertainer provides the Foreword. Fun for readers of all ages, The Laughing Desert is ideal for those who love the history, literature, humor, romance and colorful landscape unique to the American West. It's a unique gift and a great resource for classrooms or book groups; the replicas are filled with material teachers at all levels may use to liven up discussions about desert life and Arizona literature and history. Readers will smile as they follow the quirky adventures of Dick Wick Hall, his seven-year-old Frog that could not swim, and desert characters such as Chloride Kate, the Reptyle Kid, Cactus Callie, Gila Monster Jake and cub reporter Archie Bald Doveface. As an early ad for the paper put it, if you enjoy the great outdoors and laugh at the West of Mark Twain, Owen Wister and Charlie Chaplin "you will be hilarious over the Salome Sun." Each 8.5 by 11 inch issue of the 4-column paper fits on a separate page. DISCOUNT CODE AVAILABLE FOR SCHOOLS, COLLEGES, LIBRARIES, MUSEUMS, STORES AND ANY ORDERS OF FIVE OR MORE COPIES. CONTACT [email protected]. For more information about the Hall family and Dick's daughter Jane Hall's journey from Salome to Hollywood where she was an MGM screenwriter during the studio's Golden Age, see www.robinrcutler.com

This scarce antiquarian book is a selection from Kessinger PublishingA AcentsAcentsa A-Acentsa Acentss Legacy Reprint Series. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment to protecting, preserving, and promoting the world's literature. Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of intere