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This book, the proceedings of Falk Symposium 100, Gut and the
Liver', held in Freiburg, Germany, 29-31 May 1997, comprehensively
reviews the physiological and pathophysiological interactions
between the intestine and the liver as well as between intestinal
and hepatic diseases. Apart from the basic aspects of the
intestinal microflora and the immune system of the gut,
gastrointestinal permeability and translocation as well as the
contribution of the intestine and the intestinal bacteria to the
metabolism of bile acids, amino acids and drugs are discussed. In
addition, experimental as well as clinical data demonstrating the
significance of gut-derived bacterial toxins for the development of
liver diseases and the effect of liver diseases on gastrointestinal
functions are discussed. The major aim of this book, therefore, is
to highlight the interactions between gut and liver at the
molecular level as well as in clinical disease.
Although the first description of patients with what we now call
Crohn's disease or ulcerative colitis was published well before
1900, both disorders seem to be diseases of the twentieth century.
At the very start of the twenty-first century, it therefore seems
appropriate to look back and at the same time look forward and to
assess what knowledge has been gained during the last 100 years and
in what direction research and thereby clinical practice will go in
the future. This book, the proceedings of Falk Symposium No. 111
held in Freiburg, Germany, on June 19-20 1999, contains
contributions from experienced senior scientists on the state of
the art in pathophysiology, diagnosis and treatment, together with
unpublished and new findings from young researchers. Basic
scientists and clinicians are thereby involved in an exchange of
information which will lead to new directions for future research
and clinical management of inflammatory bowel diseases.
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