This book brings together presentations of some of the fundamental new research that has begun to appear in the areas of dynamic structural modeling, nonlinear structural modeling, time series modeling, nonparametric inference, and chaotic attractor inference. The contents of this volume comprise the proceedings of the third of a conference series entitled International Symposia in Economic Theory and Econometrics. This conference was held at the IC;s2 (Innovation, Creativity and Capital) Institute at the University of Texas at Austin on May 22-23, l986.

New methods in immunocytochemistry and hybridization techniques enable the pathologist active in diagnosis to clarify more effectively problems in the classification and prognosis of tumors. By adopting these methods into his diagnostic repertoire it will be possible to create a closer, more productive connection between morphological diagnosis and clinical work. This volume gives the reader an up-to-date general survey from international experts of the method, technique and practical application of these new procedures.

This book brings together presentations of some of the fundamental new research that has begun to appear in the areas of dynamic structural modeling, nonlinear structural modeling, time series modeling, nonparametric inference, and chaotic attractor inference. The contents of this volume comprise the proceedings of the third of a conference series entitled International Symposia in Economic Theory and Econometrics. This conference was held at the IC;s2 (Innovation, Creativity and Capital) Institute at the University of Texas at Austin on May 22-23, l986.

There is intense interest among scholars and the public about the risks, benefits, and pricing of pharmaceuticals but relatively little attention has been devoted to vaccine markets and the political, economic, and regulatory factors that influence their development. In this important new study, Ernst R. Berndt, Rena N. Denoncourt, and Anjli C. Warner investigate the key business drivers and challenges of vaccine markets, the complex interactions among their important stakeholders, and the emerging opportunities for growth. U.S. Markets for Vaccines: Characteristics, Case Studies, and Controversies examines several case studies including vaccines for diphtheria, tetanus, pertussis, seasonal influenza, chicken pox, and shingles that demonstrate the diverse dynamics of vaccine markets. The authors consider the role of intellectual property protection in the discovery process, preclinical and clinical development issues, manufacturing and cost characteristics, and the challenges of marketing, product differentiation, pricing, and distribution. They also explore the process of obtaining regulatory approval from the U.S. Food and Drug Administration and earning a spot on the Centers for Disease Control and Prevention's vaccination schedules for pediatric and adult populations. Finally, the authors address the controversial debate over an alleged link between childhood vaccinations and autism. Drawing upon extensive interviews with representatives from industry, insurance providers, government agencies, health-care providers, and academia, U.S. Markets for Vaccines offers a balanced and comprehensive snapshot of the changing landscape for vaccine markets.