Large-scale, interoperable biobanks are an increasingly important asset in today's life science research and, as a result, multiple types of biobanks are being established around the globe with very different financial, organizational and legal set-ups. With interdisciplinary chapters written by lawyers, sociologists, doctors and biobank practitioners, Global Genes, Local Concerns identifies and discusses the most pressing issues in contemporary biobanking. This timely book addresses pressing questions such as: how do national biobanks best contribute to translational research?; What are the opportunities and challenges that current regulations present for translational use of biobanks?; How does inter-biobank coordination and collaboration occur on various levels?; and how could academic and industrial exploitation, ownership and IPR issues be addressed and facilitated? Identifying that biobanks foundational and operational set-ups should be legally and ethically sound, while at the same time reflecting the hopes and concerns of all the involved stakeholders, this book contributes to the continued development of international biobanking by highlighting and analysing the complexities in this important area of research. Academics in the fields of law and ethics, health law and biomedical law, as well as biobank managers and policymakers will find this insightful book a stimulating and engaging read. Contributors include: T. Bossow, T.A. Caulfield, B.J. Clark, A. Hellstadius, J.R. Herrmann, K. Hoyer, M. Jordan, J. Kaye, N.C.H. Kongsholm, K. Liddell, J. Liddicoat, M.J. Madison, T. Minssen, B. Murdoch, W. Nicholson Price II, E. Ortega-Paino, M. Prictor, M.B. Rasmussen, K. Sargsyan, J. Schovsbo, A.M. Tupasela, E. van Zimmeren, F. Vogl, H. Yu, P.K. Yu

"Hydrology" by R.Hermann; "Outdoor Ponds: Their Construction Management, andUse in Experimental Ecotoxicology" by N.O. C rossland, C.J.M. Wolff; "Hydrolysis of Organic Chemicals" by T. Mill, W. Mabey; "Exchange of Pollutants and Other Substances Between the Atmosphere and the Oceans" by M.Waldichuk; "Root-Soil Interactions" by P.B. Tinker, P. Barraclough,"Reaction Types in the Environment" by C.M. Menzie.

Although in hindsight the end of the Cold War seems almost inevitable, almost no one saw it coming and there is little consensus over why it ended. A popular interpretation is that the Soviet Union was unable to compete in terms of power, especially in the area of high technology. Another interpretation gives primacy to the new ideas Gorbachev brought to the Kremlin and to the importance of leaders and domestic considerations. In this volume, prominent experts on Soviet affairs and the Cold War interrogate these competing interpretations in the context of five "turning points" in the end of the Cold War process. Relying on new information gathered in oral history interviews and archival research, the authors draw into doubt triumphal interpretation that rely on a single variable like the superior power of the United States and call attention to the importance of how multiple factors combined and were sequenced historically. The volume closes with chapters drawing lessons from the end of the Cold War for both policy making and theory building.

Although in hindsight the end of the Cold War seems almost inevitable, almost no one saw it coming and there is little consensus over why it ended. A popular interpretation is that the Soviet Union was unable to compete in terms of power, especially in the area of high technology. Another interpretation gives primacy to the new ideas Gorbachev brought to the Kremlin and to the importance of leaders and domestic considerations. In this volume, prominent experts on Soviet affairs and the Cold War interrogate these competing interpretations in the context of five "turning points" in the end of the Cold War process. Relying on new information gathered in oral history interviews and archival research, the authors draw into doubt triumphal interpretation that rely on a single variable like the superior power of the United States and call attention to the importance of how multiple factors combined and were sequenced historically. The volume closes with chapters drawing lessons from the end of the Cold War for both policy making and theory building.

This brief examines proactive steps police can take to lessen the potential for disaster, improve preparedness for disasters that do occur and enhance our ability to respond to and recover from them. Featuring several countries across the globe as case studies, it illustrates the predictability of various natural and manmade disasters and the need of the local police organizations to develop contingency plans to save lives and structures. With disaster losses and the human toll reaching staggering rates, and even more destructive events projected for the future as the climate shifts, there is a need for action by police and the local communities together. This volume offers a proactive plan that needs to be put in place for future crises, based on the projected predictability of reoccurring events. The brief can serve as a template for other countries and police task forces that have and will face similar crises situations in the future.

This brief examines 36,263 homicides in Chicago over a 53-year study period, 1965 through 2017, at micro place grid cells of 150 by 150 meters. This study shows not only long-term historical patterns of homicides in Chicago, but also places that historical context of homicide in reference to the dramatic increases in homicides in 2016-2017. It uses several different inequality metrics, as well as kernel density maps to demonstrate that homicides were more clustered in the 1960's compared to later periods. Using zero inflated group-based trajectory models, it demonstrates the long-term temporal stability of homicides at micro places. This brief will be of interest to researchers in policing, homicide, and research methods in criminology.

Fundiertes Praxiswissen zu Diagnostik sowie etablierten und neuen Therapiemoeglichkeiten bei Rektumtumoren: - Anatomische Grundlagen, Untersuchungstechniken, Therapieformen, exakte Operationstechniken - Transanale, parasakrale und transanalendoskopische Verfahren - Spektrum, Wirkungsweise und Indikation neoadjuvanter, adjuvanter und additiver Therapiearten =>NEU und einzigartig in diesem Buch: - Analyse und vergleichende Gegenuberstellung der verschiedenen Rekonstruktionsverfahren - Ausfuhrliche Darstellung der ileozoekalen Interposition als neuer Methode zum Rektumersatz Anwendungsgerechte Konzeption: - Abklarungsalgorithmen zur schnellen Entscheidungsfindung - anschauliche farbige Graphiken zu den Operationstechniken Ein Nachschlagewerk, mit dem Sie zuverlassig, schnell und kompetent arbeiten koennen. Bestellen Sie jetzt Ihr Exemplar und sichern Sie sich Ihren Wissensvorsprung in der kolorektalen Chirurgie!

In den vergangenen Jahren fUhrten die zuHillige Zuord- nung von Patienten in alternative Behandlungsverfahren (Randomisation) und die Frage der AufkHlrung zu Mei- nungsverschiedenheiten zwischen Juristen una onkolo- gisch tatigen Medizinern. Urn diese Kontroversen ausfUhr- lich zu erortern und nach Moglichkeit einen Konsens zu erreichen, fUhrte der AusschuB Onkologie des Klinikums- vorstandes der Universitat Heidelberg am 9. und 10. De- zember 1983 in der Akademie der Wissenschaften einen Workshop durch uber die "Randomisation und Aufk1a- rung bei klinischen Therapiestudien in der Onkologie". 6 Juristen, 27 Mediziner und 3 wissenschaftliche Mitarbei- ter von pharmazeutischen Firmen aus Frankfurt, Freiburg, Gottingen, Munster, Augsburg, Kaiserlautern und Heidel- berg waren Teilnehmer. Nach einleitenden Referaten wur- den die medizinischen und juristischen Gesichtspunkte diskutiert. Die mit onkologischen Fragestellungen befaB- ten Mediziner begriiBten die Auseinandersetzung mit den Juristen, urn uber die Darlegung eigener Standpunkte hin- aus zu einer Annaherung zu kommen. Diese fand ihren Ausdruck in "Empfehlungen zur Randomisation und Auf- klarung bei Therapiestudien in der Onkologie", die uber- einstimmend gebilligt wurden. In monographischer Form werden die Referate und die Empfehlungen einem groBe- ren Kreis von interessierten Juristen und Medizinern vor- gestellt.

Das vorliegende Gutachten tragt der Entwicklung der wissenschaftlichen Erkenntnis und den Erfahrungen Rechnung, die bei der praktischen Anwendung inaktivierter Kinderlahmungsimpfstoffe in der Zeit vom Winter 1955 bis Ende 1957 gesammelt worden sind. Wie das am 28. Januar 1956 vorgelegte Gutachten des Bundesgesundheitsamtes gliedert es sich in zwei Hauptteile, das Hauptgutachtcn und die wisscnschaftlichcn Abhandlungcn. In dem Hauptgutachten sind die wesent- lichen Ergebnisse der wissenschaftlichen Literatur sowie eigener experimenteller Arbeiten und sonstiger wissenschaftlicher Untersuchungen niedergelegt. Bei der Fertigstellung des Gutachtens stand den zustandigen Mitarbeitern des Bundes- gesundheitsamtes wiederum der Rat des Wissenschaftlichen Beirates zur Ver- fUgung, der sich aus folgenden Herren zusammensetzt: Prof. Dr. Dr. EYER Direktor des Hygiene-Instituts der Universitat Miinchen Prof. Dr. HERREN Direktor des Pharmakologischen Institus der Freien Universitat Berlin Prof. Dr. HORING Leitender Arzt der Infektionsabteilung des RudolfVirchow-Kranken- hauses Berlin Prof. Dr. PETTE Direktor der Neurologischen Universitatsklinik Hamburg Prof. Dr. SEIFFERT Ministerialdirigent a. D., Miinchen Prof. Dr. TRAUB Prasident der Bundesforschungsanstalt fUr Viruskrankheiten der Tiere, Tiibingen Prof. Dr. WEBER Direktor der Kinderpoliklinik der Universitat Miinchen Das Hauptgutachten ist von der Gesamtheit der an der Bearbeitung dieses Gutachtens Beteiligten gebilligt worden. Die wissenschaftliche Verantwortung fUr die Abhandlungen tragen die einzelnen Autoren. Die wissenschaftliche und redak- tionelle Bearbeitung des Gesamtgutachtens lag in den Handen von Prof. Dr. HENNEBERG, Prof. Dr. LUNDT und Frau Dr. PRYM.