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Parkinson's disease is the second most common neurodegenerative
disorder in the world after Alzheimer's disease. Thanks to the
pioneering works of Arvid Carlson in the 20th century identifying
dopamine as the main neurochemical agent involved in Parkinson's
disease's onset and progress, our understanding of the
neuropathology has increased. The elaboration of L-Dopa as the
first pharmacological treatment approach has brought new hope for
curing or at least slowing the neurodegenerative progress and the
decline of motor and cognitive functions in Parkinson's disease
patients. To date, imaging techniques along with genetic and
biochemical tools have allowed scientists and clinicians to predict
and diagnose the disease several years prior to the motor
disorder's appearance. Experimental and Clinical Evidence of the
Neuropathology of Parkinson's Disease sheds light on the history of
Parkinson's disease as well as the recent literature on the
epidemiological data worldwide including the prevalence of the
disease, the morbimortality rates, and the sex dimorphism and aging
components. It addresses the current neuropathological evidence of
Parkinson's disease, including the latest discoveries in terms of
neuropathology and treatments available or under clinical trials
with the efficacy and limitations of each. Covering topics such as
epidemiology, stem cells, and neuropathology, this premier
reference source is an excellent resource for clinicians,
physicians, epidemiologists, neuroscientists, microbiologists,
biochemists, pharmacologists, toxicologists, medical professionals,
nurses, medical students and educators, librarians, researchers,
and academicians.
This volume presents the recent developments on the biomedical
applications of chitosan and its derivatives. Chitosan exhibits
unique properties such as non-toxicity, biodegradability and
biocompatibility. Since its chemical structure and properties can
be easily modified, it can be an ideal candidate as a biomaterial.
Consequently, chitosan and its derivatives are being developed in
different forms such as nanoparticles, micelles, nanofibers,
hydrogels, films and 3D porous materials for various biomedical
applications, ranging from drug and gene delivery to tissue
engineering and regenerative medicine. The chapters of this volume
focus on the potential use of chitosan and its derivatives as a
hemostatic agent, tissue sealants, tissue engineering scaffolds,
delivery carriers for bioactive molecules in bone tissue
engineering and wound dressings. Some chapter's deal with recent
advancements of chitosan-based biomaterials as a drug, gene and
transdermal drug delivery carrier. In addition, the volume focusses
on the prospects of chitosan-based systems for the treatment of
cancer, eye and other infectious diseases. The volume will be of
interest to material scientists, chemists and biotechnologists by
providing a better understanding of the physicochemical and
biological characteristics of chitosan and its derivatives to
develop more appropriate and innovative chitosan-based materials
modified for unlimited practical applications in biomedical fields.
This volume deals with chemical modification, structure-property
relationship, biological interaction and biomedical applications of
chitosan and its chemically modified derivatives. The chapters of
this volume provide an overview of the structural comparison of
chitosan with other sugar-based biopolymers, a different type of
strategy used in chemical modification of chitosan to interact with
metal ions and to enhance antimicrobial activity. The chapters
further discuss the development of functionalized chitosan
hydrogels, films, scaffolds and composites that have the potential
to be used in food packaging, enhancing saltiness, biosensors and
wound dressing. In addition the fabrication and biological
properties of chitosan and its derivatives-based nanofibers are
presented. Another important aspect covered in this volume is that
of the interaction of chitosan with blood, platelet-rich plasma and
stem cells. Finally, this volume presents the current challenges in
the development of biomedical products based on chitosan and its
derivatives. The volume will be of interest to chemists, material
science, biological science and biomaterial scientists can able to
understand structure-property relationship, biological interaction
and biomedical applications of chitosan and its derivatives.
Polymeric Nanoparticles of Chitosan Derivatives as DNA and siRNA
Carriers, by Y. K. Kim, H. L. Jiang, Y. J. Choi, I. K. Park, M. H.
Cho and C. S. Cho.- Chitosan and Its Derivatives for Drug Delivery
Perspective, by T. A. Sonia and C. P. Sharma.- Chitosan-based
Nanoparticles in Cancer Therapy, by V.-K. Lakshmanan, K. S. Snima,
J. D. Bumgardner, S. V. Nair, and R. Jayakumar.- Chitosan and
Thiolated Chitosan, by F. Sarti and A. Bernkop-Schnurch.-
Chitosan-Based Particulate Systems for Non-Invasive Vaccine
Delivery, by S. Senel.- Multifunctional Chitosan Nanoparticles for
Tumor Imaging and Therapy, by J. Y. Yhee, Heebeom Koo, Dong Eun
Lee, Kuiwon Choi, Ick Chan Kwon and Kwangmeyung Kim.-
Chitosan-Coated Iron Oxide Nanoparticles for Molecular Imaging and
Drug Delivery, by H. Arami, Z. Stephen, O. Veiseh and M. Zhang.-
Chitosan: Its Applications in Drug-Eluting Devices, by Mei -Chin
Chen, Fwu -Long Mi, Zi -Xian Liao and Hsing -Wen Sung.-
This volume deals with the various fabrication techniques, surface
functionalization and biomedical applications of polymeric fibers
possessing different scale and structure. It provides an overview
of fabrication techniques such as Co-axial, Centrifugal, Melt and
Yarning to procure multiscale, tubular and layered fibrous scaffold
employed for biomedical applications. The chapters in this volume
discusse the surface/chemical functionalization of fibers which
enhance the biological properties of the fibrous scaffolds as well
as the development of hybrid, layered and external
stimuli-responsive fibrous scaffolds that hold potential
application in biosensor and other biomedical fields. In addition,
recent advances and applications of polymeric multiscale fibers in
tissue engineering, regenerative medicine and drug delivery are
presented. The potential use of fibrous scaffolds in bone, neural,
tendon/ligament and cardiac tissue engineering, nanofibers as an
antimicrobial wound dressing, employed in cancer theragnostics and
in the treatment of skin/periodontal infections are discussed. The
volume provides expert knowledge on the fabrication techniques,
development of different scale and hybrid structure fibers, surface
functionalization, layered and external stimuli responsive fibrous
scaffolds. It will be beneficial to material/biomaterials
scientists, bioengineering and biotechnologists by providing a
better understanding on the subject of the innovative applications
of fibrous scaffolds in drug delivery, tissue engineering, wound
dressings and regenerative medicine.
This volume presents the recent developments on the biomedical
applications of chitosan and its derivatives. Chitosan exhibits
unique properties such as non-toxicity, biodegradability and
biocompatibility. Since its chemical structure and properties can
be easily modified, it can be an ideal candidate as a biomaterial.
Consequently, chitosan and its derivatives are being developed in
different forms such as nanoparticles, micelles, nanofibers,
hydrogels, films and 3D porous materials for various biomedical
applications, ranging from drug and gene delivery to tissue
engineering and regenerative medicine. The chapters of this volume
focus on the potential use of chitosan and its derivatives as a
hemostatic agent, tissue sealants, tissue engineering scaffolds,
delivery carriers for bioactive molecules in bone tissue
engineering and wound dressings. Some chapter's deal with recent
advancements of chitosan-based biomaterials as a drug, gene and
transdermal drug delivery carrier. In addition, the volume focusses
on the prospects of chitosan-based systems for the treatment of
cancer, eye and other infectious diseases. The volume will be of
interest to material scientists, chemists and biotechnologists by
providing a better understanding of the physicochemical and
biological characteristics of chitosan and its derivatives to
develop more appropriate and innovative chitosan-based materials
modified for unlimited practical applications in biomedical fields.
Polymeric Nanoparticles of Chitosan Derivatives as DNA and siRNA
Carriers, by Y. K. Kim, H. L. Jiang, Y. J. Choi, I. K. Park, M. H.
Cho and C. S. Cho.- Chitosan and Its Derivatives for Drug Delivery
Perspective, by T. A. Sonia and C. P. Sharma.- Chitosan-based
Nanoparticles in Cancer Therapy, by V.-K. Lakshmanan, K. S. Snima,
J. D. Bumgardner, S. V. Nair, and R. Jayakumar.- Chitosan and
Thiolated Chitosan, by F. Sarti and A. Bernkop-Schnurch.-
Chitosan-Based Particulate Systems for Non-Invasive Vaccine
Delivery, by S. enel.- Multifunctional Chitosan Nanoparticles for
Tumor Imaging and Therapy, by J. Y. Yhee, Heebeom Koo, Dong Eun
Lee, Kuiwon Choi, Ick Chan Kwon and Kwangmeyung Kim.-
Chitosan-Coated Iron Oxide Nanoparticles for Molecular Imaging and
Drug Delivery, by H. Arami, Z. Stephen, O. Veiseh and M. Zhang.-
Chitosan: Its Applications in Drug-Eluting Devices, by Mei -Chin
Chen, Fwu -Long Mi, Zi -Xian Liao and Hsing -Wen Sung.-"
This volume deals with chemical modification, structure-property
relationship, biological interaction and biomedical applications of
chitosan and its chemically modified derivatives. The chapters of
this volume provide an overview of the structural comparison of
chitosan with other sugar-based biopolymers, a different type of
strategy used in chemical modification of chitosan to interact with
metal ions and to enhance antimicrobial activity. The chapters
further discuss the development of functionalized chitosan
hydrogels, films, scaffolds and composites that have the potential
to be used in food packaging, enhancing saltiness, biosensors and
wound dressing. In addition the fabrication and biological
properties of chitosan and its derivatives-based nanofibers are
presented. Another important aspect covered in this volume is that
of the interaction of chitosan with blood, platelet-rich plasma and
stem cells. Finally, this volume presents the current challenges in
the development of biomedical products based on chitosan and its
derivatives. The volume will be of interest to chemists, material
science, biological science and biomaterial scientists can able to
understand structure-property relationship, biological interaction
and biomedical applications of chitosan and its derivatives.
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