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The DNA of all organisms is constantly being damaged by endogenous
and exogenous sources. Oxygen metabolism generates reactive species
that can damage DNA, proteins and other organic compounds in living
cells. Exogenous sources include ionizing and ultraviolet
radiations, carcinogenic compounds and environmental toxins among
others. The discovery of multiple DNA lesions and DNA repair
mechanisms showed the involvement of DNA damage and DNA repair in
the pathogenesis of many human diseases, most notably cancer. These
books provide a comprehensive overview of the interdisciplinary
area of DNA damage and DNA repair, and their relevance to disease
pathology. Edited by recognised leaders in the field, this
two-volume set is an appealing resource to a variety of readers
including chemists, chemical biologists, geneticists, cancer
researchers and drug discovery scientists.
The DNA of all organisms is constantly being damaged by endogenous
and exogenous sources. Oxygen metabolism generates reactive species
that can damage DNA, proteins and other organic compounds in living
cells. Exogenous sources include ionizing and ultraviolet
radiations, carcinogenic compounds and environmental toxins among
others. The discovery of multiple DNA lesions and DNA repair
mechanisms showed the involvement of DNA damage and DNA repair in
the pathogenesis of many human diseases, most notably cancer. These
books provide a comprehensive overview of the interdisciplinary
area of DNA damage and DNA repair, and their relevance to disease
pathology. Edited by recognised leaders in the field, this
two-volume set is an appealing resource to a variety of readers
including chemists, chemical biologists, geneticists, cancer
researchers and drug discovery scientists.
The DNA of all organisms is constantly being damaged by endogenous
and exogenous sources. Oxygen metabolism generates reactive species
that can damage DNA, proteins and other organic compounds in living
cells. Exogenous sources include ionizing and ultraviolet
radiations, carcinogenic compounds and environmental toxins among
others. The discovery of multiple DNA lesions and DNA repair
mechanisms showed the involvement of DNA damage and DNA repair in
the pathogenesis of many human diseases, most notably cancer. These
books provide a comprehensive overview of the interdisciplinary
area of DNA damage and DNA repair, and their relevance to disease
pathology. Edited by recognised leaders in the field, this
two-volume set is an appealing resource to a variety of readers
including chemists, chemical biologists, geneticists, cancer
researchers and drug discovery scientists.
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