Systems biology is a relatively new biological study field that focuses on the systematic study of complex interactions in biological systems, thus using a new perspective (integration instead of reduction) to study them. Particularly from year 2000 onwards, the term is used widely in the biosciences, and in a variety of contexts. Systems biology is the study of the interconnected aspect of molecular, cellular, tissue, whole animal and ecological processes, and comprises mathematical and mechanistic studies of dynamical, mesoscopic, open, spatiotemporally defined, nonlinear, complex systems that are far from thermodynamic equilibrium.Containing a unique selection of new and updated, high-quality articles from the well-known Meyer's Encyclopedia of Molecular Cell Biology and Molecular Medicine, this two-volume handbook is an essential guide for students and researchers wishing to get an overview of the field.

Epigenetics is a term in biology referring to heritable traits that do not involve changes in the underlying DNA sequence of the organism. Epigenetic traits exist on top of or in addition to the traditional molecular basis for inheritance. The "epigenome" is a parallel to the word "genome," and refers to the overall epigenetic state of a cell. Cancer and stem cell research have gradually focused attention on these genome modifications. The molecular basis of epigenetics involves modifications to DNA and the chromatin proteins that associate with it. Methylation, for example, can silence a nearby gene and seems to be involved in some cancers. Epigenetics is beginning to form and take shape as a new scientific discipline, which will have a major impact on Medicine and essentially all fields of biology. Increasingly, researchers are unearthing links between epigenetics and a number of diseases. Although in recent years cancer has been the main focus of epigenetics, recent data suggests that epigenetic plays a critical role in psychology and psychopathology. It is being realized that normal behaviors such as maternal care and pathologies such as Schizophrenia and Alzheimer's might have an epigenetic basis. It is also becoming clear that nutrition and life experiences have epigenetic consequences. Discover more online content in the Encyclopedia of Molecular Cell Biology and Molecular Medicine.

It is essential all auditors performing Yellow Book audits understand the recently revised concepts and standards of generally accepted government auditing standards (GAGAS). This book provides a baseline of information for accountants to gain an understanding of the new Yellow Book (2018 revision of Government Auditing Standards). Featuring new guidance related to independence and peer review, this book will increase your knowledge of the requirements and application guidance related to: Ethics Independence Standards for financial audits Attestation engagements Performance audits Key topics covered include: Foundation and principles for the use and application of generally accepted government auditing standards (GAGAS) General requirements for complying with the Yellow Book Ethics, independence, and professional judgment Competence and continuing professional education Quality control and peer review Standards for financial audits Standards for attestation engagements and reviews of financial statements Fieldwork standards for performance audits Reporting standards for performance audits

This 2 volume set is a carefully chosen collection of articles on pharmacology from the successful R.A. Meyer's "Encyclopedia of Molecular Cell Biology and Molecular Medicine," The book is divided into four sections covering general aspects of drug development as well as more focused sections on cancer and gene therapy.

This collection of high-quality articles on pharmacology includes essential reading on the hottest topics of the field and is an invaluable resource for all pharmacologists, medicinal chemists and cell biologists. No science or medical library should be without this book. It is also essential reading for everybody working in the pharmaceutical industry.

Hallmark features: Uniform structure of the articles makes them very easy to use Designed for readers at any level of expertise Every chapter usefully includes: a keyword glossary a concise summary of the article comprehensive references to guide the reader deeper into the literature Derived from the "Encyclopedia of Molecular Cell Biology and Molecular Medicine," the most comprehensive and most detailed treatment of molecular biology, cell biology and molecular medicine available - designed in collaboration with a founding board of 12 Nobel laureates, including the 2007 Nobel Prize winner in medicine, Sir Martin Evans

Praise for the "Encyclopedia of Molecular Cell Biology and Molecular Medicine: "

"This series can be recommended without hesitation to a broad readership including students and qualified researchers... articles... set-up facilitates easy reading and rapid understanding... overwhelming amount of valuable data."
--"Molecular Biology Reports"

.,." It goes without saying that no librarycan afford to be without this [Encyclopedia]. Everyone working in the areas of molecular biology, genome research, medical science, or clinical research needs to have access to these volumes..."
--"Angewandte Chemie"

The largest high-level encyclopedia on molecular medicine is now publishing a topical volume on Nanomedicine. The long awaited volume gives a comprehensive overview on nanomaterials in drug delivery, imaging and as therapeutics.

The first complete overview of progress in the field. The two volumes contain selected articles from the prestigious online Encyclopedia of Molecular Cell Biology and Molecular Medicine, fully updated and enriched with numerous new contributions from many eminent scientists. Divided into three parts, the first gives a thorough introduction to cancer biology, while Part Two covers therapeutic approaches for all major forms of cancer, and the third part deals with cancer diagnostics. The result is a one-stop resource for advanced students, postdoctoral researchers and start-up companies.

This third in the Current Topics in Molecular Cell Biology and Molecular Medicine Series contains a careful selection of new and updated, high-quality articles from the well-known Meyer's Encyclopedia, describing new perspectives in stem cell research. The 26 chapters are divided into four sections: Basic Biology, Stem Cells and Disease, Stem Cell Therapy Approaches, and Laboratory Methods, with the authors chosen from among the leaders in their respective fields.
This volume represents an essential guide for students and researchers seeking an overview of the field.

This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification of appropriate targets and screening methods for the identification of compounds interacting with these targets. The rest of book covers the whole downstream pipeline after the identification of lead compounds, such as bioavailability issues, identification of appropriate drug delivery venues, production and scaling issues and preclinical trials. As has been the case with other works in the encyclopedia, the book is made up of long, comprehensive and authoritative chapters, written by outstanding researchers in the field.

This topical volume in the respected Encyclopedia series is the first in many years to bring together all important aspects of developmental biology in one source, from morphogenesis and organogenesis, via epigenetic regulation of gene expression to evolutionary developmental biology. The editor-in-chief has assembled an outstanding team of contributors to review these topics, creating an authoritative work for many years to come. The result is a unique, top-level reference in developmental biology for researchers, students and professionals alike.

This is one volume 'library' of information on molecular biology, molecular medicine, and the theory and techniques for understanding, modifying, manipulating, expressing, and synthesizing biological molecules, conformations, and aggregates. The purpose is to assist the expanding number of scientists entering molecular biology research and biotechnology applications from diverse backgrounds, including biology and medicine, as well as physics, chemistry, mathematics, and engineering.

A concise up-to-date guide to all aspects of environmental pollution and cleanup.

Human invention and innovation have brought about tremendous improvements in the quality of life of millions of people around the world today—but progress has its price. Environmental pollution is rapidly attacking the Earth's ecosphere. While advances have been made and new disciplines have emerged to identify, monitor, regulate, and compensate for environmental pollutants, it will take the combined efforts of numerous specialists to solve the problem. It will also take the efforts of an informed public that, through its voting and buying habits, has the power to determine whether or not the threat to our environment can be contained.

This 2-volume encyclopedia provides all readers, regardless of scientific background or training, with a working knowledge of contemporary issues in environmental pollution and cleanup. Based on Wiley's critically acclaimed, 8-volume Encyclopedia of Environmental Analysis and Remediation, this compact A-to-Z reference features the same breadth and quality of coverage—and clarity of presentation—found in the original. It includes:

• Over 200 self-contained, thoroughly cross-referenced articles on essential aspects of environmental pollution and cleanup.
• Coverage of key topics in hazardous waste, air pollution control, biosphere pollution, health effects, nuclear waste, environmental law and regulation, water reclamation, and more.
• Integrated coverage of both legal and policy issues and technological and environmental concerns.
• Hundreds of photographs, figures, charts, and tables that help illustrate major points, explain difficult material, and summarize important data.
• Bibliographic entries keyed to the text that list sources of additional information on selected topics.