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The ribosome is a macromolecular machine that synthesizes proteins
with a high degree of speed and accuracy. Our present understanding
of its structure, function and dynamics is the result of six
decades of research. This book collects over 40 articles based on
the talks presented at the 2010 Ribosome Meeting, held in Orvieto,
Italy, covering all facets of the structure and function of the
ribosome. New high-resolution crystal structures of functional
ribosome complexes and cryo-EM structures of translating ribosomes
are presented, while partial reactions of translation are examined
in structural and mechanistic detail, featuring translocation as a
most dynamic process. Mechanisms of initiation, both in bacterial
and eukaryotic systems, translation termination, and novel details
of the functions of the respective factors are described. Structure
and interactions of the nascent peptide within, and emerging from,
the ribosomal peptide exit tunnel are addressed in several
articles. Structural and single-molecule studies reveal a picture
of the ribosome exhibiting the energy landscape of a processive
Brownian machine. The collection provides up-to-date reviews which
will serve as a source of essential information for years to come.
A sturdy keyboard attached to a book of well-known tunes, with
colour-coded notes so that anyone can play them. Tunes include
Twinkle, Twinkle, Frere Jacques, Ode to Joy and Row, Row, Row your
Boat and there are ideas for making up simple tunes too. Each note
is represented by a colour that corresponds to the same colour on
the keyboard, so even very young children can pick out the tunes.
With delightful illustrations, this is a lovely gift that can be
taken anywhere.
The biological world operates on a multitude of scales - from
molecules to cells to tissues to organisms to ecosystems.
Throughout all these levels runs a common thread: the communication
and onward passage of information - from cell to cell, from
organism to organism and, ultimately, from generation to
generation. But how does this information - no more than a static
repository of data - come alive to govern the processes that
constitute life? The answer lies in the concerted action of
molecular components which cooperate through a series of
carefully-regulated processes to bring the information in our
genome to life. These components and processes lie at the heart of
one of the most fascinating subjects to engage the minds of
scientists today: molecular biology. Molecular Biology: Principles
of Genome Function offers a fresh, distinctive approach to the
teaching of molecular biology. It is an approach that reflects the
challenge of teaching a subject that is in many ways unrecognizable
from the molecular biology of the 20th century - a discipline in
which our understanding has advanced immeasurably, but about which
many questions remain to be answered. It is written with several
guiding themes in mind: - A focus on key principles provides a
robust conceptual framework on which students can build a solid
understanding of the discipline; - An emphasis on the commonalities
that exist between the three kingdoms of life, and the discussion
of differences between the three kingdoms where such differences
offer instructive insights into molecular processes and components,
gives students an accurate depiction of our current understanding
of the conserved nature of molecular biology, and the differences
that underpin biological diversity; - An integrated approach
demonstrates how certain molecular phenomena have diverse impacts
on genome function by presenting them as themes that recur
throughout the book, rather than as artificially separated topics
At heart, molecular biology is an experimental science, and a
central element to the understanding of molecular biology is an
appreciation of the approaches taken to yield the information from
which concepts and principles are deduced. Yet there is also the
challenge of introducing the experimental evidence in a way that
students can readily comprehend. Molecular Biology responds to this
challenge with Experimental Approach panels, which branch off from
the text in a clearly-signposted way. These panels describe pieces
of research that have been undertaken, and which have been
particularly valuable in elucidating different aspects of molecular
biology. Each panel is carefully cross-referenced to the discussion
of key molecular biology tools and techniques, which are presented
in a dedicated chapter at the end of the book. Beyond this,
Molecular Biology further enriches the learning experience with
full-colour, custom-drawn artwork; end-of-chapter questions and
summaries; relevant suggested further readings grouped by topic;
and an extensive glossary of key terms. Among the students being
taught today are the molecular biologists of tomorrow; these
individuals will be in a position to ask fascinating questions
about fields whose complexity and sophistication become more
apparent with each year that passes. Molecular Biology: Principles
of Genome Function is the perfect introduction to this challenging,
dynamic, but ultimately fascinating discipline.
Been About a Bit by Rachel Green is an autobiography which also
vividly shows the changes in the world of fox and hare hunting (now
banned) as well as the vast changes in travelling. The author's
first adventure was hitch-hiking from UK to India! Rachel was the
first female professional hunt servant in the UK. She was never
daunted by this, but equally by no means considers herself a
‘feminist’. Her first job was with an irascible racehorse
trainer in her home county of Devon. 1957 saw her start in hunt
service, a few years later, she was the first female professional
hunt servant to tread the 'hallowed flags ' at Peterborough
Foxhound Show. One summer she took time out to work in a racing
yard in Vienna. Rachel has worked in hunting in both the USA and
Canada, the latter makes for incredulous reading. In Australia she
had jobs as diverse as canning peaches, sorting laundry and being a
Jill of all trade in a ski lodge. This volume ends in 1976 when she
vows to finish in hunt service, and ends up doing what in Ireland!
(But that’s another volume.)
Sixty-odd poems about writing, about words, about plotting and
drafting, about editing and publishing, about the trials and
successes of the publishing world. Written by a published English
novelist of urban fantasy and erotica.
A collection of the first five titles in the Coming Together: Neat
line of erotic novellas. CONTENTS: Dealing with Isabella (Jenna
Byrnes); Ryder's Mate (Wendy Stone); Tangled Roots (Giselle
Renarde); Leget's Despair (Rachel Green); The Six Swans (Annabeth
Leong) Proceeds from the sales of Coming Together: Neat
publications benefit Kiva (kiva.org) Reviews posted at the point of
sale are very much appreciated, as are blog posts, tweets
(@Coming_Together), and social networking updates. Every little bit
helps Coming Together sell more books and raise more money for
charity Thank you for supporting erotic altruism. NOTE: This
purchase also entitles you to a digital (ebook) copy of this title.
Simply forward your receipt to the publisher via the email address
below, and a ZIPped file containing PDF, EPUB, MOBI, and LIT
formats will be attached and returned. Publisher: Coming Together
(erotic.cocktail at] gmail dot] com)
A Catholic priest and a pagan priestess come together to solve the
murder of a sex-guru. Pagan priestess Meinwen Jones moves 300 miles
to meet up with a man who turns up dead. She's approached by Father
Brande, who needs her help to uncover the dead man's secrets. Why
did he have so many women around him, and why do they all have
matching tattoos? Just who was having an affair with the old lady
who hung herself, and when will the priest stop putting out
Meinwen's ritual fires? Content Warning: BDSM, Erotic pain and
violence, polyamory and murder.
Harold Waterman isn't like other boys, but when a clutch of
interfering angels decide he's going to be the Antichrist that's
going a bit too far. Stricken with a terminal illness by the angel
of pestilence, Harold summons a demon, and only then does he learn
he comes from an unusual family. Well, more unusual than even he'd
been aware of. As he and Jasfoup look for a cure, Harold discovers
not only some rather useful talents but that the world as he knows
it...isn't.
141 long and short-form poems about the life of an English novelist
and her daily walks with three dogs, her memories of rural England
and the life of a writer.
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