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Supported lipid bilayers have been used as an artificial model of
biological membranes and their interaction with 5 selected
antimicrobial peptides was studied by several experimental
techniques, mainly ellipsometry, laser scanning microscopy and
fluorescence correlation spectroscopy. The work explains basic
principles of the applied techniques focusing on their aspects
relevant to characterization of lipid bilayers. The biological
significance of antimicrobial peptides, their modes of interaction
with membranes and the basic characteristics of the selected
peptides are briefly discussed. The following text describes the
main types of experimental studies performed and the interpretation
of their results. Peptide-induced changes in lipid bilayer
morphology were characterized by ellipsometry and laser scanning
microscopy. Most interesting effects were observed in the case of
melittin, which induced formation of long lipid tubules protruding
from the bilayer. Lipid lateral diffusion measured by fluorescence
correlation spectroscopy can provide information on bilayer
organization on length-scales below resolution of optical
microscopy.
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