This book will raise awareness and spark an international collaboration amongst global leaders to research the feasibility of a globally interoperable electronic health record system to prevent the international spread of disease, document patient treatment, travel, and transmission of BSL-4 infections. The problem of the spread of disease and the lack of multinational interoperability is a global problem and requires a global effort to establish interoperable systems protocols. This book focuses on the feasibility and design of a multinational or globally interoperable electronic health record system to track and prevent the spread of disease of BSL-4 infections. Due to the rapid spread of COVID-19 and the history of the multinational spread of zoonotic diseases, it is clear that a global effort is needed. The WHO stated that the lack of EHR interoperability and the spread of disease is a global problem that requires a global solution. This book is a critical exploration on this topic.